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    Zfyve9 zinc finger FYVE-type containing 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313477, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zfyve9provided by RGD
    Official Full Name
    zinc finger FYVE-type containing 9provided by RGD
    Primary source
    RGD:1310856
    See related
    Ensembl:ENSRNOG00000027183 AllianceGenome:RGD:1310856
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity and protein domain specific binding activity. Predicted to be involved in endosomal transport and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 162.9), Muscle (RPKM 136.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfyve9 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128599379..128758394, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123370677..123529699, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128233096..128392675, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene origin recognition complex, subunit 1 Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene ribosomal protein L9, pseudogene 8 Neighboring gene basic transcription factor 3-like 4 Neighboring gene thioredoxin domain containing 12 Neighboring gene KTI12 chromatin associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of SARA in Axon and Dendrite Growth. Arias CI, et al. PLoS One, 2015. PMID 26405814, Free PMC Article
    2. [Dynamic characteristics of SARA during liver fibrogenesis in rats]. Tao YY, et al. Zhonghua Gan Zang Bing Za Zhi, 2006 Dec. PMID 17196135
    3. Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy. Yu W, et al. Synapse, 2017 Mar. PMID 28035691
    4. Early endosomal regulation of Smad-dependent signaling in endothelial cells. Panopoulou E, et al. J Biol Chem, 2002 May 17. PMID 11877415
    5. Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. Chong PA, et al. J Biol Chem, 2004 Sep 24. PMID 15231848

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 9
    Names
    zinc finger, FYVE domain containing 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107952.1 → NP_001101422.1  zinc finger FYVE domain-containing protein 9

      See identical proteins and their annotated locations for NP_001101422.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474008
      UniProtKB/TrEMBL
      A6JYW0, D3ZDC7
      Related
      ENSRNOP00000036295.7, ENSRNOT00000037523.7
      Conserved Domains (3) summary
      cd15729
      Location:663 → 730
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:746 → 784
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:1021 → 1373
      DUF3480; Domain of unknown function (DUF3480)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      128599379..128758394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287713.1 → XP_063143783.1  zinc finger FYVE domain-containing protein 9 isoform X4

    2. XM_063287714.1 → XP_063143784.1  zinc finger FYVE domain-containing protein 9 isoform X4

    3. XM_063287711.1 → XP_063143781.1  zinc finger FYVE domain-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A6JYW0, D3ZDC7

    4. XM_063287712.1 → XP_063143782.1  zinc finger FYVE domain-containing protein 9 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZV6

    5. XM_039109963.2 → XP_038965891.1  zinc finger FYVE domain-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A6JYW0, D3ZDC7
      Conserved Domains (3) summary
      cd15729
      Location:663 → 730
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:746 → 784
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:1021 → 1373
      DUF3480; Domain of unknown function (DUF3480)

    6. XM_039109964.2 → XP_038965892.1  zinc finger FYVE domain-containing protein 9 isoform X2

      Conserved Domains (3) summary
      cd15729
      Location:663 → 730
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:746 → 784
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:1021 → 1345
      DUF3480; Domain of unknown function (DUF3480)
    Nucleotide Protein Strain
    Heading Accession and Version

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