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    Tnpo1 transportin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309126, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tnpo1provided by RGD
    Official Full Name
    transportin 1provided by RGD
    Primary source
    RGD:1308372
    See related
    Ensembl:ENSRNOG00000014999 AllianceGenome:RGD:1308372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 275.3), Adrenal (RPKM 268.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnpo1 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31941731..32034366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (30207529..30300162, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (29056219..29126882, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 171 Neighboring gene Histone deacetylase 1, pseudogene 8 Neighboring gene FCH and mu domain containing endocytic adaptor 2 Neighboring gene eukaryotic translation initiation factor 5B like Neighboring gene H2B.L histone variant 1 Neighboring gene uncharacterized LOC134485826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Bonifaci N, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144189, Free PMC Article
    2. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
    3. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transportin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100692.2 → NP_001094162.1  transportin-1 isoform b

      See identical proteins and their annotated locations for NP_001094162.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    2. NM_001399431.1 → NP_001386360.1  transportin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Conserved Domains (2) summary
      COG5215
      Location:32 → 767
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:103 → 124
      HEAT; HEAT repeat [structural motif]

    3. NM_001399432.1 → NP_001386361.1  transportin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AG33
      Related
      ENSRNOP00000092200.1, ENSRNOT00000110663.1
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      31941731..32034366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102145.2 → XP_038958073.1  transportin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    2. XM_039102144.2 → XP_038958072.1  transportin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    3. XM_006231840.5 → XP_006231902.1  transportin-1 isoform X1

      See identical proteins and their annotated locations for XP_006231902.1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    4. XM_008760668.4 → XP_008758890.1  transportin-1 isoform X1

      See identical proteins and their annotated locations for XP_008758890.1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Related
      ENSRNOP00000020543.8
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    5. XM_063281688.1 → XP_063137758.1  transportin-1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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