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    ZNF146 zinc finger protein 146 [ Homo sapiens (human) ]

    Gene ID: 7705, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF146provided by HGNC
    Official Full Name
    zinc finger protein 146provided by HGNC
    Primary source
    HGNC:HGNC:12931
    See related
    Ensembl:ENSG00000167635 MIM:601505; AllianceGenome:HGNC:12931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OZF
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.8), endometrium (RPKM 19.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF146 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36214723..36238768)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38763116..38787183)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36706008..36729670)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14519 Neighboring gene calpain small subunit 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36646245-36646976 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678024-36678563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678564-36679102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36683570-36684070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36684071-36684571 Neighboring gene zinc finger protein 565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14521 Neighboring gene uncharacterized LOC107985304 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724474-36724976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724977-36725478 Neighboring gene MPRA-validated peak3458 silencer Neighboring gene MPRA-validated peak3459 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36735657-36736645 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36736677-36736900 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:36737634-36738622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36748697-36749315 Neighboring gene uncharacterized LOC124904707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36759575-36760152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36762631-36763222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36770206-36770810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36775291-36775913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36786728-36787343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36787344-36787958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36790483-36791084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36791085-36791685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36793635-36794244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36796811-36797424 Neighboring gene uncharacterized LOC100134317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains. Pibouin L, et al. Cytogenet Cell Genet, 2001. PMID 11306801
    2. Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas. Ferbus D, et al. Int J Cancer, 1999 Jan 29. PMID 9935176
    3. Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs. Ferbus D, et al. Eur J Biochem, 1996 Mar 15. PMID 8665923
    4. The OZF gene encodes a protein consisting essentially of zinc finger motifs. Le Chalony C, et al. J Mol Biol, 1994 Feb 18. PMID 8107129
    5. ZNF146/OZF and ZNF507 target LINE-1 sequences. Creamer KM, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100360, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis.
      Title: Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis.
    2. ZNF146/OZF and ZNF507 target LINE-1 sequences.
      Title: ZNF146/OZF and ZNF507 target LINE-1 sequences.
    3. LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146.
      Title: LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146.
    4. OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress.
      Title: OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress.
    5. OZF overexpression in tumours may alter the balance between hRap1 and other telomeric proteins; therefore OZF function may be linked to telomere regulation
      Title: Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.
    6. OZF interacts with UBC9, the E2 enzyme involved in the covalent conjugation of the small ubiquitin-like modifier 1 (SUMO-1).
      Title: A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125660, MGC125661

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein OZF
    Names
    only zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099638.2 → NP_001093108.1  zinc finger protein OZF

      See identical proteins and their annotated locations for NP_001093108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI039686, BC065568, DA645504, DA806687, DR155969
      Consensus CDS
      CCDS12492.1
      UniProtKB/Swiss-Prot
      Q15072, Q2TB94
      Related
      ENSP00000400391.1, ENST00000456324.5
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:74 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001099639.2 → NP_001093109.1  zinc finger protein OZF

      See identical proteins and their annotated locations for NP_001093109.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI039686, BC065568, CN409203, DA645504, DB068031, DR155969
      Consensus CDS
      CCDS12492.1
      UniProtKB/Swiss-Prot
      Q15072, Q2TB94
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:74 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    3. NM_007145.3 → NP_009076.2  zinc finger protein OZF

      See identical proteins and their annotated locations for NP_009076.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI039686, BC065568, DA395000, DA645504, DR155969
      Consensus CDS
      CCDS12492.1
      UniProtKB/Swiss-Prot
      Q15072, Q2TB94
      Related
      ENSP00000392095.1, ENST00000443387.3
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:74 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36214723..36238768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439366.1 → XP_047295322.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    2. XM_017027247.3 → XP_016882736.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:74 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047439367.1 → XP_047295323.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    4. XM_047439365.1 → XP_047295321.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    5. XM_017027246.3 → XP_016882735.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:74 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    6. XM_047439368.1 → XP_047295324.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    7. XM_005259214.4 → XP_005259271.1  zinc finger protein OZF isoform X1

      See identical proteins and their annotated locations for XP_005259271.1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:74 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38763116..38787183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322012.1 → XP_054177987.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    2. XM_054322015.1 → XP_054177990.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    3. XM_054322016.1 → XP_054177991.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    4. XM_054322013.1 → XP_054177988.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    5. XM_054322014.1 → XP_054177989.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    6. XM_054322010.1 → XP_054177985.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94

    7. XM_054322011.1 → XP_054177986.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      Q15072, Q2TB94
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15072.2 GenPept UniProtKB/Swiss-Prot:Q15072

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