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    RNF182 ring finger protein 182 [ Homo sapiens (human) ]

    Gene ID: 221687, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RNF182provided by HGNC
    Official Full Name
    ring finger protein 182provided by HGNC
    Primary source
    HGNC:HGNC:28522
    See related
    Ensembl:ENSG00000180537 AllianceGenome:HGNC:28522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 4.5), bone marrow (RPKM 2.7) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF182 in Genome Data Viewer
    Location:
    6p23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (13924446..13980310)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13796680..13852762)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13924677..13980541)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901264 Neighboring gene Sharpr-MPRA regulatory region 2979 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:13755870-13756079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24039 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:13769328-13769828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13787884-13788716 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:13789385-13789553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16939 Neighboring gene uncharacterized LOC107986571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24040 Neighboring gene mitochondrial calcium uniporter regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13872467-13873049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16941 Neighboring gene CRISPRi-validated cis-regulatory element chr6.697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:13924078-13924578 Neighboring gene NANOG hESC enhancer GRCh37_chr6:13944174-13944689 Neighboring gene mitochondrial ribosomal protein L35 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr6.702 Neighboring gene CRISPRi-validated cis-regulatory element chr6.703 Neighboring gene CRISPRi-validated cis-regulatory element chr6.704 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:14001334-14002533 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:14035147-14036346 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:14069795-14069896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24042 Neighboring gene NANOG hESC enhancer GRCh37_chr6:14088959-14089460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24043 Neighboring gene CRISPRi-FlowFISH-validated CD83 regulatory element GRCh37_chr6:14095567-14096067 Neighboring gene uncharacterized LOC105374939 Neighboring gene CRISPRi-validated cis-regulatory element chr6.709 Neighboring gene uncharacterized LOC124901265

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma. Zeng X, et al. Immun Inflamm Dis, 2023 May. PMID 37249301, Free PMC Article
    2. The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation. Cao Y, et al. FEBS Lett, 2019 Nov. PMID 31432514
    3. Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia-reperfusion injury. Wang JH, et al. J Cell Biochem, 2019 May. PMID 30450663
    4. PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma. Liu Y, et al. Oncogene, 2022 Jul. PMID 35688944
    5. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. Okamoto T, et al. Int J Mol Sci, 2020 May 30. PMID 32486221, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma.
      Title: RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma.
    2. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
      Title: The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
    3. E3 ubiquitin ligase RNF182 is highly expressed in macrophages and is specifically upregulated by Toll-like receptors (TLR) stimuli (TLR4, TLR3 and TLR9 agonists). Knockdown of RNF182 selectively amplifies TLR signaling by promoting the production of proinflammatory cytokines but not type I interferons in macrophages.
      Title: The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40772, MGC33993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF182
    Names
    RING-type E3 ubiquitin transferase RNF182
    NP_001158504.1
    NP_001158505.1
    NP_001158506.1
    NP_689950.1
    XP_016865939.1
    XP_047274326.1
    XP_047274327.1
    XP_054210605.1
    XP_054210606.1
    XP_054210607.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165032.2 → NP_001158504.1  E3 ubiquitin-protein ligase RNF182

      See identical proteins and their annotated locations for NP_001158504.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AL138718, AW731636, BC030666, BC050030, DA803766, DB094450
      Consensus CDS
      CCDS4531.1
      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3
      Related
      ENSP00000442021.1, ENST00000544682.5
      Conserved Domains (1) summary
      cd16555
      Location:19 → 69
      RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

    2. NM_001165033.2 → NP_001158505.1  E3 ubiquitin-protein ligase RNF182

      See identical proteins and their annotated locations for NP_001158505.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK090576, AL138718, AW731636, BC030666, BC050030, DB176198
      Consensus CDS
      CCDS4531.1
      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3
      Related
      ENSP00000441271.1, ENST00000537388.1
      Conserved Domains (1) summary
      cd16555
      Location:19 → 69
      RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

    3. NM_001165034.2 → NP_001158506.1  E3 ubiquitin-protein ligase RNF182

      See identical proteins and their annotated locations for NP_001158506.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AL138718, AW731636, BC030666, BC050030, DA123125
      Consensus CDS
      CCDS4531.1
      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3
      Related
      ENSP00000443228.1, ENST00000537663.5
      Conserved Domains (1) summary
      cd16555
      Location:19 → 69
      RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

    4. NM_152737.4 → NP_689950.1  E3 ubiquitin-protein ligase RNF182

      See identical proteins and their annotated locations for NP_689950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK315528, AL138718, AW731636, BC030666, BC050030
      Consensus CDS
      CCDS4531.1
      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3
      Related
      ENSP00000420465.1, ENST00000488300.6
      Conserved Domains (1) summary
      cd16555
      Location:19 → 69
      RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      13924446..13980310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010450.3 → XP_016865939.1  E3 ubiquitin-protein ligase RNF182 isoform X1

      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3
      Conserved Domains (1) summary
      cd16555
      Location:19 → 69
      RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

    2. XM_047418370.1 → XP_047274326.1  E3 ubiquitin-protein ligase RNF182 isoform X1

      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3

    3. XM_047418371.1 → XP_047274327.1  E3 ubiquitin-protein ligase RNF182 isoform X1

      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      13796680..13852762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354632.1 → XP_054210607.1  E3 ubiquitin-protein ligase RNF182 isoform X1

      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3

    2. XM_054354630.1 → XP_054210605.1  E3 ubiquitin-protein ligase RNF182 isoform X1

      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3

    3. XM_054354631.1 → XP_054210606.1  E3 ubiquitin-protein ligase RNF182 isoform X1

      UniProtKB/Swiss-Prot
      B2RDG2, Q8N6D2, Q8NBG3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6D2.1 GenPept UniProtKB/Swiss-Prot:Q8N6D2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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