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    DACT3 dishevelled binding antagonist of beta catenin 3 [ Homo sapiens (human) ]

    Gene ID: 147906, updated on 5-Mar-2024

    Summary

    Official Symbol
    DACT3provided by HGNC
    Official Full Name
    dishevelled binding antagonist of beta catenin 3provided by HGNC
    Primary source
    HGNC:HGNC:30745
    See related
    Ensembl:ENSG00000197380 MIM:611112; AllianceGenome:HGNC:30745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RRR1; DAPPER3
    Summary
    Predicted to enable delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cell growth. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 11.1), endometrium (RPKM 7.4) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DACT3 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46647551..46661182, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49473085..49486718, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47150808..47164439, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calmodulin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47119779-47120280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47120281-47120780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47124126-47124640 Neighboring gene prostaglandin I2 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47128561-47129061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10816 Neighboring gene Sharpr-MPRA regulatory region 2120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10818 Neighboring gene G protein subunit gamma 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47157789-47158515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10821 Neighboring gene DACT3 antisense RNA 1 Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47200828-47201328 Neighboring gene microRNA 320e

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC15476

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables delta-catenin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dapper homolog 3
    Names
    antagonist of beta-catenin Dapper homolog 3
    arginine-rich region 1 protein
    dapper, antagonist of beta-catenin, homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301046.2NP_001287975.1  dapper homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_001287975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC093503, AI769079, BC016161, BE274342, BF515069, BX097198
      Consensus CDS
      CCDS74402.1
      UniProtKB/TrEMBL
      A0A0C4DFP1
      Related
      ENSP00000300875.4, ENST00000300875.4
      Conserved Domains (1) summary
      pfam15268
      Location:22404
      Dapper; Dapper
    2. NM_145056.3NP_659493.2  dapper homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_659493.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC093503
      Consensus CDS
      CCDS12688.2
      UniProtKB/Swiss-Prot
      Q96B18
      Related
      ENSP00000375783.2, ENST00000391916.7
      Conserved Domains (1) summary
      pfam15268
      Location:20629
      Dapper; Dapper

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46647551..46661182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526499.3XP_011524801.1  dapper homolog 3 isoform X2

      See identical proteins and their annotated locations for XP_011524801.1

      UniProtKB/TrEMBL
      A0A0C4DFP1
      Conserved Domains (1) summary
      pfam15268
      Location:22404
      Dapper; Dapper
    2. XM_017026334.2XP_016881823.1  dapper homolog 3 isoform X1

    3. XM_011526500.3XP_011524802.1  dapper homolog 3 isoform X2

      See identical proteins and their annotated locations for XP_011524802.1

      UniProtKB/TrEMBL
      A0A0C4DFP1
      Conserved Domains (1) summary
      pfam15268
      Location:22404
      Dapper; Dapper

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      49473085..49486718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319897.1XP_054175872.1  dapper homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DFP1
    2. XM_054319896.1XP_054175871.1  dapper homolog 3 isoform X1

    3. XM_054319898.1XP_054175873.1  dapper homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DFP1