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    Gtf3c3 general transcription factor IIIC, polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 98488, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gtf3c3provided by MGI
    Official Full Name
    general transcription factor IIIC, polypeptide 3provided by MGI
    Primary source
    MGI:MGI:2138383
    See related
    Ensembl:ENSMUSG00000041303 AllianceGenome:MGI:2138383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TFIIIC102; TF3C-gamma
    Summary
    Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in testis. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.2), CNS E18 (RPKM 5.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf3c3 in Genome Data Viewer
    Location:
    1 C1.2; 1 27.13 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (54435036..54478185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (54395877..54439026, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51622 Neighboring gene STARR-seq mESC enhancer starr_00932 Neighboring gene predicted gene, 25829 Neighboring gene coiled-coil domain containing 150 Neighboring gene STARR-seq mESC enhancer starr_00933 Neighboring gene STARR-seq mESC enhancer starr_00934 Neighboring gene STARR-seq mESC enhancer starr_00935 Neighboring gene predicted gene, 34066 Neighboring gene STARR-seq mESC enhancer starr_00936 Neighboring gene post-GPI attachment to proteins 1 Neighboring gene predicted gene, 51623

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Moniot B, et al. Development, 2014 Sep. PMID 25142465
    2. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    3. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase III general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor 3C polypeptide 3
    Names
    TFIIIC 102 kDa subunit
    transcription factor IIIC-gamma subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033194.3 → NP_001028366.1  general transcription factor 3C polypeptide 3

      See identical proteins and their annotated locations for NP_001028366.1

      Status: VALIDATED

      Source sequence(s)
      AC124538, BC141157, BY272879
      Consensus CDS
      CCDS14958.1
      UniProtKB/TrEMBL
      Q3TMP1
      Related
      ENSMUSP00000039420.7, ENSMUST00000041638.8
      Conserved Domains (3) summary
      sd00006
      Location:179 → 207
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:212 → 276
      TPR_11; TPR repeat
      pfam13432
      Location:421 → 485
      TPR_16; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      54435036..54478185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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