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    BNIP2 BCL2 interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 663, updated on 5-Mar-2024

    Summary

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    Official Symbol
    BNIP2provided by HGNC
    Official Full Name
    BCL2 interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:1083
    See related
    Ensembl:ENSG00000140299 MIM:603292; AllianceGenome:HGNC:1083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIP2; BNIP-2
    Summary
    This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.4), fat (RPKM 13.5) and 24 other tissues See more
    Orthologs
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    Genomic context

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    See BNIP2 in Genome Data Viewer
    Location:
    15q22.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (59659146..59689320, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57460850..57491038, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59951345..59981519, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene RNA, 5S ribosomal pseudogene 396 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:59908775-59909010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9499 Neighboring gene general transcription factor IIA subunit 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:59981225-59981873 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1 Neighboring gene RPS3A pseudogene 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:60095821-60096349 Neighboring gene MPRA-validated peak2359 silencer Neighboring gene DEAD-box helicase 18 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation. Wong DCP, et al. Adv Sci (Weinh), 2022 Nov. PMID 35975420, Free PMC Article
    2. BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation. Pan M, et al. Sci Adv, 2020 Jul. PMID 32789168, Free PMC Article
    3. Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing. Scott GB, et al. Biochem J, 2010 Nov 1. PMID 20704564
    4. Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2. Belcredito S, et al. Brain Res Brain Res Rev, 2001 Nov. PMID 11744098
    5. BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1. Akamatsu R, et al. Genes Cells, 2015 Feb. PMID 25472445

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation.
      Title: BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation.
    2. BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation.
      Title: BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation.
    3. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine.
      Title: BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
    4. BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain.
      Title: KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.
    5. Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2.
      Title: SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.
    6. Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing.
      Title: Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
    8. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities.
      Title: Cleavage of BNIP-2 and BNIP-XL by caspases.
    9. BNIP-2 in vivo induces cell dynamics by recruiting Cdc42
      Title: BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.
    10. BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1
      Title: Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to oxygen-glucose deprivation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
    Names
    BCL2/adenovirus E1B 19kDa interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029765.2 RefSeqGene

      Range
      5124..35298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320674.2 → NP_001307603.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC092755
      Consensus CDS
      CCDS92007.1
      UniProtKB/TrEMBL
      H7C096
      Related
      ENSP00000393644.2, ENST00000439052.6

    2. NM_001320675.4 → NP_001307604.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092755
      Consensus CDS
      CCDS10174.3
      UniProtKB/Swiss-Prot
      B4DS94, Q12982
      Related
      ENSP00000412767.3, ENST00000415213.7
      Conserved Domains (2) summary
      cd00170
      Location:147 → 290
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:49 → 163
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    3. NM_001368057.1 → NP_001354986.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092755

    4. NM_001368058.1 → NP_001354987.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC092755

    5. NM_001368059.1 → NP_001354988.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC092755

    6. NM_001368060.1 → NP_001354989.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC092755

    7. NM_001368061.1 → NP_001354990.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC092755

    8. NM_004330.4 → NP_004321.3  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092755
      Consensus CDS
      CCDS10174.3
      UniProtKB/Swiss-Prot
      B4DS94, Q12982
      Related
      ENSP00000475320.1, ENST00000607373.6
      Conserved Domains (2) summary
      cd00170
      Location:147 → 290
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:49 → 163
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      59659146..59689320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      57460850..57491038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12982.1 GenPept UniProtKB/Swiss-Prot:Q12982

    Gene LinkOut

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