Heatr5b HEAT repeat containing 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Heatr5bprovided by MGI
Official Full Name: HEAT repeat containing 5Bprovided by MGI
Primary source: MGI:MGI:2444098
See related: Ensembl:ENSMUSG00000039414 AllianceGenome:MGI:2444098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1414; 2010013B10Rik; A230048G03Rik; D330050P16Rik
Summary: Predicted to be involved in endocytosis; protein localization; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasmic vesicle. Predicted to be active in endocytic vesicle. Orthologous to human HEATR5B (HEAT repeat containing 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.6), whole brain E14.5 (RPKM 7.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E3; 17 49.54 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (79060335..79142810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (78752906..78835381, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

43.MMHAP25FRG10.seq (e-PCR)
- UniSTS:124494

SHGC-63528 (e-PCR)
- UniSTS:82322

AV071430 (e-PCR)
- UniSTS:166072

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: HEAT repeat-containing protein 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081179.1 → NP_001074648.1 HEAT repeat-containing protein 5B

See identical proteins and their annotated locations for NP_001074648.1

Status: PROVISIONAL

Source sequence(s)

AC151264, AC151284

Consensus CDS

CCDS37697.1

UniProtKB/Swiss-Prot

Q3TPS4, Q5DTY0, Q5PRF1, Q8C547, Q8C6W1, Q8C773

Related

ENSMUSP00000094882.3, ENSMUST00000097281.4

Conserved Domains (1) summary

sd00044
Location:852 → 882

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

79060335..79142810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028084.1: Suppressed sequence

Description

NM_028084.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
NM_177168.2: Suppressed sequence

Description

NM_177168.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
NM_177332.2: Suppressed sequence

Description

NM_177332.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.