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    ST13P4 ST13, Hsp70 interacting protein pseudogene 4 [ Homo sapiens (human) ]

    Gene ID: 145165, updated on 5-May-2024

    Summary

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    Official Symbol
    ST13P4provided by HGNC
    Official Full Name
    ST13, Hsp70 interacting protein pseudogene 4provided by HGNC
    Primary source
    HGNC:HGNC:18487
    See related
    AllianceGenome:HGNC:18487
    Gene type
    pseudo
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM10A4; FAM10A4P
    Summary
    Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein-containing complex assembly. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ST13P4 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (50172018..50173616)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (49392601..49394199)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50746154..50747752)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7759 Neighboring gene Sharpr-MPRA regulatory region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:50656434-50657229 Neighboring gene microRNA 15a Neighboring gene NANOG hESC enhancer GRCh37_chr13:50695956-50696481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:50699798-50700508 Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5359 Neighboring gene deleted in lymphocytic leukemia 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:50715020-50715693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7760 Neighboring gene uncharacterized LOC124900337 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:50818353-50819552 Neighboring gene NANOG hESC enhancer GRCh37_chr13:50823191-50823706 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:50850586-50851108 Neighboring gene ribosomal protein L34 pseudogene 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer. Sossey-Alaoui K, et al. Genomics, 2002 Jul. PMID 12079276
    2. Phosphoproteomic analysis of the human pituitary. Beranova-Giorgianni S, et al. Pituitary, 2006. PMID 16807684
    3. A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells. Russo LC, et al. J Proteomics, 2017 Jan 16. PMID 27371349
    4. Multiple common variants for celiac disease influencing immune gene expression. Dubois PC, et al. Nat Genet, 2010 Apr. PMID 20190752, Free PMC Article
    5. PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. Guardia-Laguarta C, et al. J Neurosci, 2019 Sep 4. PMID 31300519, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. establishement of conditions to specifically undertake mutation studies of this chromosome 13 member
      Title: Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • ST13-like tumor suppressor
    • family with sequence similarity 10, member A4 pseudogene
    • suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 4

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002183.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AF539468

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      50172018..50173616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      49392601..49394199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153290.1: Suppressed sequence

      Description
      NM_153290.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZP2.1 GenPept UniProtKB/Swiss-Prot:Q8IZP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials