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    Plppr2 phospholipid phosphatase related 2 [ Mus musculus (house mouse) ]

    Gene ID: 235044, updated on 14-May-2024

    Summary

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    Official Symbol
    Plppr2provided by MGI
    Official Full Name
    phospholipid phosphatase related 2provided by MGI
    Primary source
    MGI:MGI:2384575
    See related
    Ensembl:ENSMUSG00000040563 AllianceGenome:MGI:2384575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lppr2; PRG-4
    Summary
    Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; forelimb bud; neural retina; and notochord. Orthologous to human PLPPR2 (phospholipid phosphatase related 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 47.3), whole brain E14.5 (RPKM 44.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plppr2 in Genome Data Viewer
    Location:
    9 A3; 9 7.92 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21848306..21860203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21935684..21948907)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RAB3D, member RAS oncogene family Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159 Neighboring gene predicted gene, 45914 Neighboring gene SWIM type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. Schierloh A, et al. Neurosci Lett, 2007 Apr 6. PMID 17316992
    2. Systematic expression analysis of plasticity-related genes in mouse brain development brings PRG4 into play. Gross I, et al. Dev Dyn, 2022 Apr. PMID 34622503
    3. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Savaskan NE, et al. Eur J Neurosci, 2004 Jan. PMID 14750979
    4. Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. Amano K, et al. J Bone Miner Res, 2015 Dec. PMID 26094741
    5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC25492

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase-related protein type 2
    Names
    inactive phospholipid phosphatase PLPPR2
    lipid phosphate phosphatase-related protein type 2
    plasticity-related gene 4 protein
    NP_001277228.1
    NP_001397525.1
    NP_001397526.1
    NP_001397527.1
    NP_659184.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290299.1 → NP_001277228.1  phospholipid phosphatase-related protein type 2 isoform 2

      See identical proteins and their annotated locations for NP_001277228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK082453, AY438023, CX122376
      Consensus CDS
      CCDS72203.1
      UniProtKB/Swiss-Prot
      Q8VCY8
      Related
      ENSMUSP00000038616.7, ENSMUST00000046371.13
      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_001410596.1 → NP_001397525.1  phospholipid phosphatase-related protein type 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166992
      UniProtKB/TrEMBL
      A0A087WQF0
      Related
      ENSMUSP00000140166.2, ENSMUST00000188468.2

    3. NM_001410597.1 → NP_001397526.1  phospholipid phosphatase-related protein type 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166992
      UniProtKB/Swiss-Prot
      Q8BIE4, Q8VCY8

    4. NM_001410598.1 → NP_001397527.1  phospholipid phosphatase-related protein type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166992

    5. NM_144935.1 → NP_659184.1  phospholipid phosphatase-related protein type 2 isoform 1

      See identical proteins and their annotated locations for NP_659184.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      BC018242
      Consensus CDS
      CCDS80966.1
      UniProtKB/Swiss-Prot
      Q8BIE4, Q8VCY8
      Related
      ENSMUSP00000139727.2, ENSMUST00000190387.7
      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21848306..21860203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCY8.1 GenPept UniProtKB/Swiss-Prot:Q8VCY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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