Esam endothelial cell-specific adhesion molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esamprovided by MGI
Official Full Name: endothelial cell-specific adhesion moleculeprovided by MGI
Primary source: MGI:MGI:1916774
See related: Ensembl:ENSMUSG00000001946 AllianceGenome:MGI:1916774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Esam1; W117m; 2310008D05Rik
Summary: Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Located in adherens junction; bicellular tight junction; and plasma membrane. Is expressed in several structures, including cardiovascular system; liver; lung; nervous system; and placenta. Orthologous to human ESAM (endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 97.8), subcutaneous fat pad adult (RPKM 50.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.77 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (37439385..37449615)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (37528089..37538319)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses.
Title: Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses.
Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos.
Title: Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos.
ESAM expression in hematopoietic progenitors is essential for erythroid recovery after a bone marrow injury.
Title: Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury.
Runx3 is required for cell identity, homeostasis and function of splenic Esam(high) dendritic cells.
Title: Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3.
ESAM levels clearly mirror the shift of hematopoietic stem cells (HSC) between quiescence and activation, and the intensity of expression is prominent in comparison with other HSC-related antigens.
Title: The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.
ESAM regulates tumor metastasis through endothelial cell migration and tube formation in metastatic nodules.
Title: Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis.
ESAM inactivation can reduce susceptibility to atherosclerosis by inhibiting plaque neovascularization and macrophage infiltration into the atheroma.
Title: Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction.
findings support a model in which ESAM localizes to platelet contacts following platelet activation in order to limit thrombus growth and stability
Title: Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo.
Thus, ESAM may regulate albumin extravasation at the glomeruli and play a role in the initiation of diabetic nephropathy.
Title: Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy.
ESAM marks hematopoietic stem cells in murine fetal liver and will facilitate studies of hematopoiesis throughout life.
Title: The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelial cell-selective adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027102.3 → NP_081378.1 endothelial cell-selective adhesion molecule precursor

See identical proteins and their annotated locations for NP_081378.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript.

Source sequence(s)

AI414314, AK009223, BG077536, BQ043033, BY119695, CJ048383

Consensus CDS

CCDS22979.1

UniProtKB/Swiss-Prot

Q925F2

UniProtKB/TrEMBL

Q3U102

Related

ENSMUSP00000002011.8, ENSMUST00000002011.14

Conserved Domains (3) summary

smart00408
Location:170 → 234

IGc2; Immunoglobulin C-2 Type

smart00410
Location:169 → 244

IG_like; Immunoglobulin like

pfam07686
Location:42 → 153

V-set; Immunoglobulin V-set domain

RNA

NR_136939.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC105958, AI414314