Vasn vasorin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vasnprovided by MGI
Official Full Name: vasorinprovided by MGI
Primary source: MGI:MGI:2177651
See related: Ensembl:ENSMUSG00000039646 AllianceGenome:MGI:2177651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atia; Slitl2; 2610528G05Rik
Summary: Predicted to enable transforming growth factor beta binding activity. Acts upstream of or within cellular response to hypoxia and cellular response to redox state. Located in mitochondrion and plasma membrane. Is expressed in several structures, including cardiovascular system; cranium; embryo mesenchyme; genitourinary system; and gut. Orthologous to human VASN (vasorin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 39.5), lung adult (RPKM 36.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.46 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4457809..4469030)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4639945..4651166)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vasorin plays a critical role in vascular smooth muscle cells and arterial functions.
Title: Vasorin plays a critical role in vascular smooth muscle cells and arterial functions.
Vasorin contributes to lung injury via FABP4-mediated inflammation.
Title: Vasorin contributes to lung injury via FABP4-mediated inflammation.
Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation.
Title: Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation.
Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.
Title: Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.
Vasn regulates folliculogenesis, maintenance of the ovarian reserve and ovulation.
Title: Vasorin: a newly identified regulator of ovarian folliculogenesis.
Study characterized the expression pattern of Vasn during mouse embryonic development; with various distinct expression domains, results indicate important roles for Vasn e.g., in the developing skeletal system, the kidneys, and the lungs.
Title: Expression of vasorin (Vasn) during embryonic development of the mouse.
ATIA is an HIF-1 target that regulates mitochondrial redox pathways.
Title: A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transforming growth factor beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to redox state	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vasorin

Names: Slit-like 2; protein slit-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139307.3 → NP_647468.2 vasorin precursor

See identical proteins and their annotated locations for NP_647468.2

Status: VALIDATED

Source sequence(s)

AI448688, AK132325, BF657819

Consensus CDS

CCDS27921.1

UniProtKB/Swiss-Prot

Q8BJJ0, Q8R2G5, Q9CZT5

Related

ENSMUSP00000045162.4, ENSMUST00000038770.4

Conserved Domains (8) summary

smart00013
Location:24 → 55

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:299 → 350

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:76 → 273

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:35 → 57

LRR_RI; leucine-rich repeat [structural motif]

pfam00008
Location:410 → 441

EGF; EGF-like domain

pfam00041
Location:468 → 537

fn3; Fibronectin type III domain

pfam12799
Location:77 → 118

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:102 → 161

LRR_8; Leucine rich repeat