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    Mettl22 methyltransferase 22, Kin17 lysine [ Mus musculus (house mouse) ]

    Gene ID: 239706, updated on 4-May-2024

    Summary

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    Official Symbol
    Mettl22provided by MGI
    Official Full Name
    methyltransferase 22, Kin17 lysineprovided by MGI
    Primary source
    MGI:MGI:2384301
    See related
    Ensembl:ENSMUSG00000039345 AllianceGenome:MGI:2384301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable heat shock protein binding activity and protein methyltransferase activity. Predicted to be involved in protein methylation. Predicted to act upstream of or within methylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human METTL22 (methyltransferase 22, Kin17 lysine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 31.3), CNS E18 (RPKM 14.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl22 in Genome Data Viewer
    Location:
    16 A1; 16 3.97 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8288623..8308069)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8470757..8490205)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8406840-8407023 Neighboring gene STARR-positive B cell enhancer ABC_E8615 Neighboring gene predicted gene, 24579 Neighboring gene transmembrane protein 114 Neighboring gene predicted gene, 30012 Neighboring gene predicted gene, 23706 Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene STARR-seq mESC enhancer starr_40005 Neighboring gene zinc finger, MYND domain containing 19 pseudogene Neighboring gene ferritin light chain 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC38788

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methyltransferase-like protein 22
    Names
    methyltransferase like 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417199.1 → NP_001404128.1  methyltransferase-like protein 22 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123851

    2. NM_001417200.1 → NP_001404129.1  methyltransferase-like protein 22 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123851

    3. NM_001417203.1 → NP_001404132.1  methyltransferase-like protein 22 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123851

    4. NM_001417204.1 → NP_001404133.1  methyltransferase-like protein 22 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123851

    5. NM_001417205.1 → NP_001404134.1  methyltransferase-like protein 22 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC123851

    6. NM_001417206.1 → NP_001404135.1  methyltransferase-like protein 22 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC123851

    7. NM_146247.2 → NP_666359.1  methyltransferase-like protein 22 isoform 1

      See identical proteins and their annotated locations for NP_666359.1

      Status: VALIDATED

      Source sequence(s)
      AC123851
      Consensus CDS
      CCDS27938.1
      UniProtKB/Swiss-Prot
      Q3UW48, Q8R1C6
      Related
      ENSMUSP00000044108.10, ENSMUST00000046470.16
      Conserved Domains (1) summary
      cl17173
      Location:169 → 326
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_184430.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123851

    2. NR_184431.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123851

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      8288623..8308069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522107.5 → XP_006522170.1  methyltransferase-like protein 22 isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:86 → 243
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1C6.1 GenPept UniProtKB/Swiss-Prot:Q8R1C6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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