MIR618 microRNA 618 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR618provided by HGNC
Official Full Name: microRNA 618provided by HGNC
Primary source: HGNC:HGNC:32874
See related: Ensembl:ENSG00000208022 miRBase:MI0003632; AllianceGenome:HGNC:32874
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN618; mir-618; hsa-mir-618
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 12q21.31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (80935736..80935833, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (80914578..80914675, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (81329515..81329612, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer.
Title: CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer.
Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4.
Title: Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4.
Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis.
Title: Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis.
Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer.
Title: Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer.
miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children.
Title: miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children.
Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case-control studies.
Title: Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case-control studies.
LINC00511 was confirmed to be beneficial for osteosarcoma development via sponging miR-618 and increasing MAEL expression
Title: Long intergenic non-protein coding RNA 511 promotes the progression of osteosarcoma cells through sponging microRNA 618 to upregulate the expression of maelstrom.
miR-618 expression levels downregulated in gastric cancer (GC) tissues. In vitro miR-618 suppressed the invasion and migration capacity of GC cells. TGF-beta2 was identified and confirmed as a downstream target of miR-618. Findings suggest that miR-618 may function as a tumor suppressor in GC and suppresses metastasis in GC by negatively regulating the transcriptional level of TGF-beta2.
Title: miR-618 Suppresses Metastasis in Gastric Cancer by Downregulating the Expression of TGF-β2.
our study revealed that polymorphism rs2682818 in miR-618 contributes to CRC susceptibility.
Title: Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population.
Circular RNA circ_0005230 was proved to be a sponge of miR-618, and expression of miR-618 could regulate CBX8 expression via targeting the 3'UTR of CBX8.
Title: Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.