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    Ppp2r2d protein phosphatase 2, regulatory subunit B, delta [ Mus musculus (house mouse) ]

    Gene ID: 52432, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ppp2r2dprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B, deltaprovided by MGI
    Primary source
    MGI:MGI:1289252
    See related
    Ensembl:ENSMUSG00000041769 AllianceGenome:MGI:1289252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDS026; D7Ertd753e; 1300017E19Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Is expressed in central nervous system and retina. Orthologous to human PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 18.0), whole brain E14.5 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp2r2d in Genome Data Viewer
    Location:
    7 F4; 7 82.95 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138448073..138484786)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (138846350..138883057)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30874 Neighboring gene STARR-seq mESC enhancer starr_20408 Neighboring gene STARR-positive B cell enhancer ABC_E11741 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_20409 Neighboring gene STARR-seq mESC enhancer starr_20411 Neighboring gene STARR-seq mESC enhancer starr_20412 Neighboring gene BCL2/adenovirus E1B interacting protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E11372 Neighboring gene gamma-glutamyl hydrolase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma. Pan W, et al. J Immunol, 2022 Aug 1. PMID 35831019, Free PMC Article
    2. In vivo discovery of immunotherapy targets in the tumour microenvironment. Zhou P, et al. Nature, 2014 Feb 6. PMID 24476824, Free PMC Article
    3. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D. Kim YS, et al. Nat Commun, 2022 Oct 14. PMID 36241614, Free PMC Article
    4. PPP2R2D suppresses IL-2 production and Treg function. Pan W, et al. JCI Insight, 2020 Oct 2. PMID 32897879, Free PMC Article
    5. Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Veloso A, et al. Cell Death Dis, 2019 Jul 4. PMID 31273193, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
      Title: Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
    2. PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
      Title: PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
    3. PPP2R2D suppresses IL-2 production and Treg function.
      Title: PPP2R2D suppresses IL-2 production and Treg function.
    4. PP2A-B55delta as the first protein phosphatase to be involved in myoblast fusion and suggest that reversible phosphorylation of HDAC4 may coordinate differentiation and fusion events during myogenesis.
      Title: Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion.
    5. In tumours, Ppp2r2d knockdown inhibited T-cell apoptosis and enhanced T-cell proliferation as well as cytokine production
      Title: In vivo discovery of immunotherapy targets in the tumour microenvironment.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347618.1 → NP_001334547.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end and uses a downstream start codon compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC149221
      Consensus CDS
      CCDS85447.1
      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    2. NM_026391.2 → NP_080667.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 1

      See identical proteins and their annotated locations for NP_080667.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC066022
      Consensus CDS
      CCDS21950.1
      UniProtKB/Swiss-Prot
      Q6ZPN5, Q925E7
      Related
      ENSMUSP00000040321.7, ENSMUST00000041097.13
      Conserved Domains (2) summary
      COG5170
      Location:14 → 448
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:37 → 85
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      138448073..138484786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508015.3 → XP_006508078.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006508078.1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    2. XM_036153235.1 → XP_036009128.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    3. XM_030242762.2 → XP_030098622.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    4. XM_030242764.2 → XP_030098624.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    5. XM_017322350.3 → XP_017177839.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    6. XM_030242766.2 → XP_030098626.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    7. XM_006508020.5 → XP_006508083.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2

      Conserved Domains (2) summary
      COG5170
      Location:31 → 280
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:68 → 119
      7WD40; WD40 repeat [structural motif]

    8. XM_030242763.1 → XP_030098623.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    9. XM_036153233.1 → XP_036009126.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Related
      ENSMUSP00000119004.2, ENSMUST00000155672.8
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    10. XM_036153234.1 → XP_036009127.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      F6RV17
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925E7.1 GenPept UniProtKB/Swiss-Prot:Q925E7

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