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    Cep95 centrosomal protein 95 [ Mus musculus (house mouse) ]

    Gene ID: 320162, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cep95provided by MGI
    Official Full Name
    centrosomal protein 95provided by MGI
    Primary source
    MGI:MGI:2443502
    See related
    Ensembl:ENSMUSG00000018372 AllianceGenome:MGI:2443502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc45; AI118346; 4732496G21Rik; D330027A14Rik; F630025I20Rik
    Summary
    Predicted to be located in centrosome. Predicted to be active in spindle pole. Orthologous to human CEP95 (centrosomal protein 95). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.1), CNS E11.5 (RPKM 8.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep95 in Genome Data Viewer
    Location:
    11 E1; 11 70.02 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106679466..106709687)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106788640..106818861)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene STARR-seq mESC enhancer starr_30947 Neighboring gene STARR-seq mESC enhancer starr_30948 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD box helicase 5 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene STARR-positive B cell enhancer ABC_E11496 Neighboring gene STARR-positive B cell enhancer ABC_E8465 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106822918-106823220 Neighboring gene Smad nuclear interacting protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
    2. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 95 kDa
    Names
    coiled-coil domain containing 45
    coiled-coil domain-containing protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166685.1 → NP_001160157.1  centrosomal protein of 95 kDa isoform 2

      See identical proteins and their annotated locations for NP_001160157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon but maintains the reading frame compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK052705, BC090675, BE852789, BU695983
      Consensus CDS
      CCDS48963.1
      UniProtKB/TrEMBL
      Q14B65
      Related
      ENSMUSP00000099357.4, ENSMUST00000103068.10
      Conserved Domains (1) summary
      TIGR02168
      Location:541 → 773
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_177088.3 → NP_796062.2  centrosomal protein of 95 kDa isoform 1

      See identical proteins and their annotated locations for NP_796062.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK052705, BC090675, BE852789, BU695983
      Consensus CDS
      CCDS25563.1
      UniProtKB/Swiss-Prot
      A2A5Z8, Q8BVV7
      Related
      ENSMUSP00000018516.5, ENSMUST00000018516.11
      Conserved Domains (2) summary
      PHA03307
      Location:191 → 360
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:584 → 816
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106679466..106709687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314609.2 → XP_017170098.1  centrosomal protein of 95 kDa isoform X3

      UniProtKB/TrEMBL
      Q8BWE9
      Conserved Domains (1) summary
      cl00030
      Location:7 → 97
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    2. XM_006533544.4 → XP_006533607.1  centrosomal protein of 95 kDa isoform X1

      Conserved Domains (3) summary
      PHA03307
      Location:191 → 360
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:541 → 773
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl00030
      Location:7 → 97
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    3. XM_036156765.1 → XP_036012658.1  centrosomal protein of 95 kDa isoform X2

      Conserved Domains (4) summary
      PHA03307
      Location:191 → 360
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:486 → 718
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam19016
      Location:55 → 107
      DUF5745; Domain of unknown function (DUF5745)
      cl00030
      Location:7 → 97
      CH_SF; calponin homology (CH) domain superfamily

    RNA

    1. XR_879703.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVV7.2 GenPept UniProtKB/Swiss-Prot:Q8BVV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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