IQGAP2 IQ motif containing GTPase activating protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IQGAP2provided by HGNC
Official Full Name: IQ motif containing GTPase activating protein 2provided by HGNC
Primary source: HGNC:HGNC:6111
See related: Ensembl:ENSG00000145703 MIM:605401; AllianceGenome:HGNC:6111
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Expression: Broad expression in liver (RPKM 36.3), duodenum (RPKM 28.2) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q13.3

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (76403285..76708132)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (76885042..77189993)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (75699110..76003957)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.
Title: Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
Title: IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.
Title: Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.
Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjogren's syndrome.
Title: Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren's syndrome.
IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.
Title: IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.
Data suggest that CDC42 binding to Ex-domain of IQGAP2 releases Ex-domain at C-terminal region of GRD2 domain, facilitating IQGAP2 dimerization; this promotes allosteric changes in ras GTPase-activating protein binding site providing binding site for second CDC42; RAC1 binds only to apo-IQGAP2. (IQGAP2 = IQ motif containing GTPase activating protein-2; CDC42 = GTP-binding protein CDC42; RAC1 = Rac family small GTPase-1)
Title: Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.
IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability
Title: Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.
The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered.
Title: The Structural Basis for Cdc42-Induced Dimerization of IQGAPs.
The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2.
Title: Targeted Sequencing and Meta-Analysis of Preterm Birth.
IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population.
Title: The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study for age-related hearing impairment in the Saami. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-11362 (e-PCR)
- UniSTS:76035

G63437 (e-PCR)
- UniSTS:140549

SHGC-144593 (e-PCR)
- UniSTS:172300

RH120796 (e-PCR)
- UniSTS:132877

RH46468 (e-PCR)
- UniSTS:91153

RH45967 (e-PCR)
- UniSTS:85781

SHGC-148469 (e-PCR)
- UniSTS:176410

D5S1678E (e-PCR)
- UniSTS:151067

RH119622 (e-PCR)
- UniSTS:133940

MARC_17727-17728:1031758304:1 (e-PCR)
- UniSTS:268387

RH70668 (e-PCR)
- UniSTS:82051

SHGC-104986 (e-PCR)
- UniSTS:169094

D5S2432 (e-PCR)
- UniSTS:78227

RH45775 (e-PCR)
- UniSTS:70293

SHGC-57970 (e-PCR)
- UniSTS:1202

SHGC-83998 (e-PCR)
- UniSTS:104628

Iqgap2 (e-PCR), detects polymorphism
- UniSTS:256441

STS-N26732 (e-PCR)
- UniSTS:64186

SHGC-144459 (e-PCR)
- UniSTS:172254

SHGC-143662 (e-PCR)
- UniSTS:172005

F2RL2_622 (e-PCR)
- UniSTS:277222

RH66695 (e-PCR)
- UniSTS:7150

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables actin binding	TAS Traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in thrombin-activated receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	TAS Traceable Author Statement more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ras GTPase-activating-like protein IQGAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_053128.2 RefSeqGene

Range

5002..309849

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001285460.2 → NP_001272389.2 ras GTPase-activating-like protein IQGAP2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC025188, AC026706, AC026725

Consensus CDS

CCDS75262.1

UniProtKB/TrEMBL

B7Z7U6, F5H7S7

Related

ENSP00000442313.2, ENST00000379730.7

Conserved Domains (4) summary

smart00015
Location:639 → 660

IQ; Calmodulin-binding motif

COG5261
Location:734 → 1525

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

cl00030
Location:1 → 116

CH_SF; calponin homology (CH) domain superfamily

cl02569
Location:866 → 1224

RasGAP; Ras GTPase Activating Domain
NM_001285461.2 → NP_001272390.2 ras GTPase-activating-like protein IQGAP2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has several differences compared to variant 1, including an alternate 5' terminal exon, use of an alternate translation initiation codon and lacking an in-frame coding exon. The resulting shorter isoform (3) has a novel N-terminus and lacks an internal protein segment compared to isoform 1.

Source sequence(s)

AC025188, AC026706, AC026725

Consensus CDS

CCDS68897.1

UniProtKB/TrEMBL

Q59HA3

Related

ENSP00000379535.3, ENST00000396234.7

Conserved Domains (3) summary

smart00456
Location:153 → 180

WW; Domain with 2 conserved Trp (W) residues

cd05131
Location:412 → 770

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

COG5261
Location:280 → 1071

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
NM_001285462.2 → NP_001272391.2 ras GTPase-activating-like protein IQGAP2 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) has several differences compared to variant 1, including an alternate 5' terminal exon, use of an alternate translation initiation codon and lacking an in-frame coding exon. The resulting shorter isoform (4) has a novel N-terminus and lacks an internal protein segment compared to isoform 1.

Source sequence(s)

AC025188, AC026706, AC026725

Consensus CDS

CCDS68898.1

UniProtKB/TrEMBL

Q59HA3

Related

ENSP00000426027.1, ENST00000502745.5

Conserved Domains (3) summary

smart00456
Location:153 → 180

WW; Domain with 2 conserved Trp (W) residues

cd05131
Location:412 → 770

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

COG5261
Location:280 → 1071

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
NM_006633.5 → NP_006624.3 ras GTPase-activating-like protein IQGAP2 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC025188, AC026706, AC026725, AC093251, AC112173

Consensus CDS

CCDS34188.1

UniProtKB/Swiss-Prot

A8K4V1, B7Z8A4, J3KR91, Q13576

UniProtKB/TrEMBL

B7Z7U6

Related

ENSP00000274364.6, ENST00000274364.11

Conserved Domains (4) summary

smart00015
Location:689 → 710

IQ; Calmodulin-binding motif

COG5261
Location:784 → 1575

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

cd21275
Location:11 → 166

CH_IQGAP2; calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP2

cl02569
Location:916 → 1274

RasGAP; Ras GTPase Activating Domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

76403285..76708132

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008960.2 → XP_016864449.1 ras GTPase-activating-like protein IQGAP2 isoform X5

UniProtKB/TrEMBL

B7Z7U6
XM_047416641.1 → XP_047272597.1 ras GTPase-activating-like protein IQGAP2 isoform X1

UniProtKB/TrEMBL

B7Z7U6
XM_005248410.4 → XP_005248467.1 ras GTPase-activating-like protein IQGAP2 isoform X3

UniProtKB/TrEMBL

B7Z7U6

Conserved Domains (3) summary

smart00015
Location:662 → 683

IQ; Calmodulin-binding motif

cd05131
Location:889 → 1247

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

cl27227
Location:757 → 1548

RasGAP_C; RasGAP C-terminus
XM_024454336.2 → XP_024310104.1 ras GTPase-activating-like protein IQGAP2 isoform X2

UniProtKB/TrEMBL

B7Z7U6

Conserved Domains (3) summary

smart00015
Location:687 → 708

IQ; Calmodulin-binding motif

cd05131
Location:914 → 1272

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

cl27227
Location:782 → 1573

RasGAP_C; RasGAP C-terminus
XM_047416643.1 → XP_047272599.1 ras GTPase-activating-like protein IQGAP2 isoform X4

UniProtKB/TrEMBL

B7Z7U6, F5H7S7
XM_047416642.1 → XP_047272598.1 ras GTPase-activating-like protein IQGAP2 isoform X4

UniProtKB/TrEMBL

B7Z7U6, F5H7S7
XM_005248414.3 → XP_005248471.1 ras GTPase-activating-like protein IQGAP2 isoform X7

UniProtKB/TrEMBL

Q59HA3

Conserved Domains (4) summary

smart00015
Location:242 → 263

IQ; Calmodulin-binding motif

cd05131
Location:469 → 827

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

smart00323
Location:458 → 787

RasGAP; GTPase-activator protein for Ras-like GTPases

pfam03836
Location:920 → 1051

RasGAP_C; RasGAP C-terminus
XM_011543108.3 → XP_011541410.1 ras GTPase-activating-like protein IQGAP2 isoform X6

UniProtKB/TrEMBL

Q59HA3

Conserved Domains (4) summary

smart00015
Location:242 → 263

IQ; Calmodulin-binding motif

cd05131
Location:469 → 827

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

smart00323
Location:458 → 787

RasGAP; GTPase-activator protein for Ras-like GTPases

pfam03836
Location:920 → 1051

RasGAP_C; RasGAP C-terminus

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

76885042..77189993

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054351462.1 → XP_054207437.1 ras GTPase-activating-like protein IQGAP2 isoform X5

UniProtKB/TrEMBL

B7Z7U6
XM_054351458.1 → XP_054207433.1 ras GTPase-activating-like protein IQGAP2 isoform X1

UniProtKB/TrEMBL

B7Z7U6
XM_054351460.1 → XP_054207435.1 ras GTPase-activating-like protein IQGAP2 isoform X3

UniProtKB/TrEMBL

B7Z7U6
XM_054351459.1 → XP_054207434.1 ras GTPase-activating-like protein IQGAP2 isoform X2

UniProtKB/TrEMBL

B7Z7U6
XM_054351461.1 → XP_054207436.1 ras GTPase-activating-like protein IQGAP2 isoform X4

UniProtKB/TrEMBL

B7Z7U6
XM_054351464.1 → XP_054207439.1 ras GTPase-activating-like protein IQGAP2 isoform X7

UniProtKB/TrEMBL

Q59HA3
XM_054351463.1 → XP_054207438.1 ras GTPase-activating-like protein IQGAP2 isoform X6

UniProtKB/TrEMBL

Q59HA3