RAB11FIP2 RAB11 family interacting protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB11FIP2provided by HGNC
Official Full Name: RAB11 family interacting protein 2provided by HGNC
Primary source: HGNC:HGNC:29152
See related: Ensembl:ENSG00000107560 MIM:608599; AllianceGenome:HGNC:29152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: nRip11; Rab11-FIP2
Summary: Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including TRAM-dependent toll-like receptor 4 signaling pathway; phagocytosis; and positive regulation of GTPase activity. Located in endosome; nucleoplasm; and phagocytic cup. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in endometrium (RPKM 12.0), brain (RPKM 9.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (118004916..118046941, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (118898958..118940990, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (119764427..119806452, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of the Rab-binding domain of Rab11 family-interacting protein 2.
Title: Crystal structure of the Rab-binding domain of Rab11 family-interacting protein 2.
Knockdown Rab11-FIP2 inhibits migration and invasion of nasopharyngeal carcinoma via suppressing Rho GTPase signaling.
Title: Knockdown Rab11-FIP2 inhibits migration and invasion of nasopharyngeal carcinoma via suppressing Rho GTPase signaling.
The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors.
Title: The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors.
miR-192/215-Rab11-FIP2 axis appears to represent a new molecular mechanism underlying gastric cancer progression.
Title: Inhibition of the miR-192/215-Rab11-FIP2 axis suppresses human gastric cancer progression.
Mechanistic investigations showed that Rab11-FIP2 interacted with the glycolytic kinase PGK1 and promoted its ubiquitination in NSCLC cells, leading to inactivation of the oncogenic AKT/mTOR signaling pathway.
Title: Rab11-FIP2 suppressed tumor growth via regulation of PGK1 ubiquitination in non-small cell lung cancer.
miR-142-3p, a microRNA enriched in exosomes during acute cellular rejection, is transferred to endothelial cells and compromises endothelial barrier function via down-regulation of RAB11FIP2.
Title: Exosomal miR-142-3p is increased during cardiac allograft rejection and augments vascular permeability through down-regulation of endothelial RAB11FIP2 expression.
an interaction of Eps15 and Rab11-FIP2 at the appropriate time and location in polarizing cells is necessary for proper establishment of epithelial polarity.
Title: Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition.
Our data suggested a potential role of Rab11-FIP2 in tumor progression and provided novel insights into the mechanism of how Rab11-FIP2 positively regulated cell migration and invasion in CRC cells.
Title: Rab11-FIP2 promotes colorectal cancer migration and invasion by regulating PI3K/AKT/MMP7 signaling pathway.
our findings reveal a novel mechanism underlying the role of Rab11-FIP2 in gastric cancer dissemination
Title: Rab11-FIP2 promotes the metastasis of gastric cancer cells.
Rab11-FIP2 binding to MYO5B is essential for vesicular trafficking in Hela and MDCK cells.
Title: Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide interaction studies reveal sex-specific asthma risk alleles. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94036 (e-PCR)
- UniSTS:89625

NoName (e-PCR)
- UniSTS:482337

D19Mgc5 (e-PCR)
- UniSTS:256836

RH91963 (e-PCR)
- UniSTS:88145

RH44480 (e-PCR)
- UniSTS:93017

SHGC-53330 (e-PCR)
- UniSTS:12665

A004P42 (e-PCR)
- UniSTS:59009

SHGC-132842 (e-PCR)
- UniSTS:170922

RH68381 (e-PCR)
- UniSTS:11484

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in phagocytic cup	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 2

Names: RAB11 family interacting protein 2 (class I)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330167.2 → NP_001317096.1 rab11 family-interacting protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC022395, DQ013303, R52658

Consensus CDS

CCDS81512.1

UniProtKB/Swiss-Prot

Q7L804

Related

ENSP00000358200.3, ENST00000369199.5

Conserved Domains (2) summary

cd08682
Location:15 → 141

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:472 → 519

RBD-FIP; FIP domain
NM_014904.3 → NP_055719.1 rab11 family-interacting protein 2 isoform 1

See identical proteins and their annotated locations for NP_055719.1

Status: VALIDATED

Source sequence(s)

AB023158, AC022395, BM975322

Consensus CDS

CCDS7602.1

UniProtKB/Swiss-Prot

A6NEI4, Q3I768, Q7L804, Q9Y2F0

Related

ENSP00000347839.3, ENST00000355624.8

Conserved Domains (2) summary

cd08682
Location:15 → 141

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:452 → 499

RBD-FIP; FIP domain