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    Mug2 murinoglobulin 2 [ Mus musculus (house mouse) ]

    Gene ID: 17837, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mug2provided by MGI
    Official Full Name
    murinoglobulin 2provided by MGI
    Primary source
    MGI:MGI:99836
    See related
    Ensembl:ENSMUSG00000030131 AllianceGenome:MGI:99836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpamd8
    Summary
    Predicted to enable endopeptidase inhibitor activity and protease binding activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human PZP (PZP alpha-2-macroglobulin like) and A2ML1 (alpha-2-macroglobulin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward liver adult (RPKM 83.2) See more
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    Genomic context

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    See Mug2 in Genome Data Viewer
    Location:
    6 F1; 6 57.52 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (121983688..122062927)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122006729..122085968)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17216 Neighboring gene predicted gene, 44173 Neighboring gene murinoglobulin 4, pseudogene Neighboring gene thymosin beta-10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17217 Neighboring gene murinoglobulin pseudogene Neighboring gene murinoglobulin, pseudogene 1 Neighboring gene predicted gene, 46974

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the murinoglobulins. Overbergh L, et al. J Biol Chem, 1991 Sep 5. PMID 1840592
    2. Identification of four genes coding for isoforms of murinoglobulin, the monomeric mouse alpha 2-macroglobulin: characterization of the exons coding for the bait region. Overbergh L, et al. Genomics, 1994 Aug. PMID 7528167
    3. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    4. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
    5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    murinoglobulin-2
    Names
    C3 and PZP-like, alpha-2-macroglobulin domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008646.3 → NP_032672.2  murinoglobulin-2 precursor

      See identical proteins and their annotated locations for NP_032672.2

      Status: VALIDATED

      Source sequence(s)
      AC153582, AC153838, AC156279
      Consensus CDS
      CCDS39619.1
      UniProtKB/Swiss-Prot
      P28666
      Related
      ENSMUSP00000080469.7, ENSMUST00000081777.8
      Conserved Domains (7) summary
      COG2373
      Location:96 → 1075
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:960 → 1241
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:740 → 830
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1353 → 1440
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1013 → 1243
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459 → 598
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      121983688..122062927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505699.2 → XP_006505762.1  murinoglobulin-2 isoform X1

      Conserved Domains (7) summary
      cd02897
      Location:960 → 1266
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:740 → 830
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1378 → 1465
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:340 → 434
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 299
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07703
      Location:459 → 599
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    2. XM_006505700.2 → XP_006505763.1  murinoglobulin-2 isoform X2

      Conserved Domains (7) summary
      cd02897
      Location:960 → 1266
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:740 → 830
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1378 → 1465
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:340 → 434
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 299
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07703
      Location:459 → 599
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    3. XM_006505701.2 → XP_006505764.1  murinoglobulin-2 isoform X3

      Conserved Domains (7) summary
      cd02897
      Location:960 → 1241
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:740 → 830
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1353 → 1440
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:340 → 434
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 299
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07703
      Location:459 → 599
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    4. XM_006505702.1 → XP_006505765.1  murinoglobulin-2 isoform X4

      Conserved Domains (6) summary
      cd02897
      Location:846 → 1152
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:626 → 716
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1264 → 1351
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:226 → 320
      MG4; Macroglobulin domain MG4
      pfam07703
      Location:345 → 485
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl19929
      Location:129 → 161
      A2M_N; MG2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28666.2 GenPept UniProtKB/Swiss-Prot:P28666

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