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    Gli4 GLI family zinc finger 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500893, updated on 11-Apr-2024

    Summary

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    Symbol
    Gli4provided by RGD
    Full Name
    GLI family zinc finger 4provided by RGD
    Primary source
    RGD:1560906
    See related
    Ensembl:ENSRNOG00000021765 AllianceGenome:RGD:1560906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human GLI4 (GLI family zinc finger 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 45.7), Kidney (RPKM 37.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gli4 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109205812..109211650)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107325584..107330911)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116671931..116677188)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 Neighboring gene zinc finger protein 41 Neighboring gene DNA topoisomerase I mitochondrial Neighboring gene uncharacterized LOC134479926 Neighboring gene rhophilin, Rho GTPase binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC114422

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein GLI4
    Names
    zinc finger protein GLI4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029926.1 → NP_001025097.1  zinc finger protein GLI4

      See identical proteins and their annotated locations for NP_001025097.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097383
      UniProtKB/TrEMBL
      Q4QR79
      Conserved Domains (3) summary
      COG5048
      Location:115 → 337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 356
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109205812..109211650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241856.5 → XP_006241918.1  zinc finger protein GLI4 isoform X1

      See identical proteins and their annotated locations for XP_006241918.1

      UniProtKB/TrEMBL
      Q4QR79
      Related
      ENSRNOP00000036983.3
      Conserved Domains (3) summary
      COG5048
      Location:115 → 337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 356
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039079757.2 → XP_038935685.1  zinc finger protein GLI4 isoform X1

      UniProtKB/TrEMBL
      Q4QR79
      Conserved Domains (3) summary
      COG5048
      Location:115 → 337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 356
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017595052.3 → XP_017450541.1  zinc finger protein GLI4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K898
      Related
      ENSRNOP00000074524.2

    4. XM_063264126.1 → XP_063120196.1  zinc finger protein GLI4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K898

    5. XM_063264125.1 → XP_063120195.1  zinc finger protein GLI4 isoform X1

      UniProtKB/TrEMBL
      Q4QR79

    6. XM_006241858.3 → XP_006241920.1  zinc finger protein GLI4 isoform X1

      See identical proteins and their annotated locations for XP_006241920.1

      UniProtKB/TrEMBL
      Q4QR79
      Conserved Domains (3) summary
      COG5048
      Location:115 → 337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 356
      zf-H2C2_2; Zinc-finger double domain

    7. XM_063264127.1 → XP_063120197.1  zinc finger protein GLI4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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