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    Rassf6 Ras association domain family member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305251, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Rassf6provided by RGD
    Official Full Name
    Ras association domain family member 6provided by RGD
    Primary source
    RGD:1566082
    See related
    Ensembl:ENSRNOG00000002866 AllianceGenome:RGD:1566082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of apoptotic process and signal transduction. Predicted to act upstream of or within positive regulation of apoptotic process. Orthologous to human RASSF6 (Ras association domain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 55.0), Kidney (RPKM 51.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rassf6 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (17717505..17757507)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17433328..17473565)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18983852..19023921)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093066 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096582 Neighboring gene albumin superfamily member 1 Neighboring gene uncharacterized LOC134481727 Neighboring gene afamin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. Iwasa H, et al. J Biol Chem, 2013 Oct 18. PMID 24003224, Free PMC Article
    2. RASSF6 is a novel member of the RASSF family of tumor suppressors. Allen NP, et al. Oncogene, 2007 Sep 13. PMID 17404571
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC114410

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 6
    Names
    Ras association (RalGDS/AF-6) domain family member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025671.2 → NP_001020842.1  ras association domain-containing protein 6

      See identical proteins and their annotated locations for NP_001020842.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q4QR82
      Related
      ENSRNOP00000003836.5, ENSRNOT00000003836.7
      Conserved Domains (2) summary
      pfam16517
      Location:291 → 329
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:191 → 277
      UBQ; Ubiquitin-like proteins

    2. NM_001428978.1 → NP_001415907.1  ras association domain-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    3. NM_001428979.1 → NP_001415908.1  ras association domain-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      17717505..17757507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250745.5 → XP_006250807.1  ras association domain-containing protein 6 isoform X2

      UniProtKB/Swiss-Prot
      Q4QR82
      Conserved Domains (2) summary
      pfam16517
      Location:291 → 329
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:191 → 277
      UBQ; Ubiquitin-like proteins

    2. XM_006250747.5 → XP_006250809.1  ras association domain-containing protein 6 isoform X2

      UniProtKB/Swiss-Prot
      Q4QR82
      Conserved Domains (2) summary
      pfam16517
      Location:291 → 329
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:191 → 277
      UBQ; Ubiquitin-like proteins

    3. XM_039091870.2 → XP_038947798.2  ras association domain-containing protein 6 isoform X3

    4. XM_008770036.3 → XP_008768258.2  ras association domain-containing protein 6 isoform X1

    5. XM_039091869.2 → XP_038947797.1  ras association domain-containing protein 6 isoform X4

      Conserved Domains (1) summary
      cl28922
      Location:94 → 180
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QR82.1 GenPept UniProtKB/Swiss-Prot:Q4QR82

    Gene LinkOut

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