Uso1 USO1 vesicle transport factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uso1provided by RGD
Official Full Name: USO1 vesicle transport factorprovided by RGD
Primary source: RGD:621604
See related: Ensembl:ENSRNOG00000002301 AllianceGenome:RGD:621604
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TAP; Vdp
Summary: Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; membrane fusion; and transcytosis. Predicted to be located in several cellular components, including Golgi apparatus; fibrillar center; and perinuclear region of cytoplasm. Predicted to be active in ER to Golgi transport vesicle membrane; Golgi stack; and endoplasmic reticulum. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 273.7), Liver (RPKM 240.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (16150921..16216389, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (15866638..15932185, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (17371451..17436948, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monomeric SNAREs are a major binding site for p115 on COPII vesicles, and that p115 dissociates from its SNARE partners upon SNAREpin assembly.
Title: p115-SNARE interactions: a dynamic cycle of p115 binding monomeric SNARE motifs and releasing assembled bundles.
Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat
Title: Coat-tether interaction in Golgi organization.
p115 coordinates sequential tethering and docking of COPI vesicles by first using long tethers (Golgins) and then short tethers (SNAREs).
Title: Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.
Regulation of this interaction by proteins such as GM130 and Giantin may control the membrane recruitment of p115 by Rab1.
Title: A cryptic Rab1-binding site in the p115 tethering protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI277889 (e-PCR)
- UniSTS:243884

RH140889 (e-PCR)
- UniSTS:222905

D14Hmgc11 (e-PCR)
- UniSTS:531413

D14Hmgc10 (e-PCR)
- UniSTS:531414

D14Hmgc9 (e-PCR)
- UniSTS:531416

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in secretory granule localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretory granule localization	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle fusion with Golgi apparatus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ER to Golgi transport vesicle membrane	TAS Traceable Author Statement more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in Golgi stack	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: general vesicular transport factor p115

Names: protein USO1 homolog; transcytosis-associated protein; vesicle docking protein, 115 kDa; vesicle-docking protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019379.2 → NP_062252.2 general vesicular transport factor p115

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P41542

UniProtKB/TrEMBL

A0A8I6A7H7, A6KKA4

Related

ENSRNOP00000087182.1, ENSRNOT00000103892.1

Conserved Domains (3) summary

COG1196
Location:656 → 932

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam04869
Location:347 → 628

Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region

pfam18770
Location:271 → 329

Arm_vescicular; Armadillo tether-repeat of vescicular transport factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

16150921..16216389 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273514.1 → XP_063129584.1 general vesicular transport factor p115 isoform X3
XM_063273513.1 → XP_063129583.1 general vesicular transport factor p115 isoform X2
XM_006250750.5 → XP_006250812.1 general vesicular transport factor p115 isoform X1

UniProtKB/TrEMBL

A0A8I6A7H7, A0A8L2Q065

Related

ENSRNOP00000003277.4

Conserved Domains (3) summary

cd00020
Location:19 → 153

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam04869
Location:347 → 635

Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region

pfam04871
Location:792 → 941

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region