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    dync1li1 dynein, cytoplasmic 1, light intermediate chain 1 [ Danio rerio (zebrafish) ]

    Gene ID: 556103, updated on 27-Mar-2024

    Summary

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    Official Symbol
    dync1li1provided by ZNC
    Official Full Name
    dynein, cytoplasmic 1, light intermediate chain 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4108
    See related
    Ensembl:ENSDARG00000098317 AllianceGenome:ZFIN:ZDB-GENE-030131-4108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dncli2; fc73a07; wu:fc73a07; si:dkey-63j1.8
    Summary
    Predicted to enable dynein heavy chain binding activity. Acts upstream of or within regulation of mitotic cell cycle, embryonic and regulation of mitotic spindle organization. Predicted to be located in cytoplasm and microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Is expressed in liver. Orthologous to human DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See dync1li1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (18989911..19026046, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (19416958..19453089, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 7 Neighboring gene CKLF-like MARVEL transmembrane domain containing 8a Neighboring gene copine IVb Neighboring gene uncharacterized LOC110438147 Neighboring gene mitochondrial ribosomal protein L3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish. Zhang J, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Apr. PMID 36682603
    2. The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Mahale S, et al. Sci Rep, 2016 Dec 23. PMID 28003657, Free PMC Article
    3. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Zhao X, et al. Sci Adv, 2021 Jun. PMID 34117063, Free PMC Article
    4. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. Drerup CM, et al. PLoS Genet, 2013. PMID 23468645, Free PMC Article
    5. Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype. Tonelli F, et al. Matrix Biol, 2020 Aug. PMID 32173581

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish.
      Title: Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein 1 light intermediate chain 1
    Names
    dynein, cytoplasmic, light intermediate chain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102428.1 → NP_001095898.1  cytoplasmic dynein 1 light intermediate chain 1

      See identical proteins and their annotated locations for NP_001095898.1

      Status: PROVISIONAL

      Source sequence(s)
      FP085415
      UniProtKB/TrEMBL
      A3KPZ3, Q1LUM9
      Related
      ENSDARP00000138705.1, ENSDART00000167951.2
      Conserved Domains (3) summary
      pfam05783
      Location:29 → 495
      DLIC; Dynein light intermediate chain (DLIC)
      pfam13238
      Location:56 → 178
      AAA_18; AAA domain
      cl21455
      Location:217 → 287
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      18989911..19026046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159514.3 → XP_005159571.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4ICI6, A0A8M2B6A0
      Related
      ENSDARP00000132385.1, ENSDART00000163359.2
      Conserved Domains (3) summary
      pfam05783
      Location:29 → 485
      DLIC; Dynein light intermediate chain (DLIC)
      pfam13238
      Location:56 → 178
      AAA_18; AAA domain
      cl21455
      Location:217 → 287
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_009294161.3 → XP_009292436.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ASH7
      Conserved Domains (3) summary
      pfam05783
      Location:29 → 452
      DLIC; Dynein light intermediate chain (DLIC)
      pfam13238
      Location:56 → 178
      AAA_18; AAA domain
      cl21455
      Location:217 → 287
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_009294160.3 → XP_009292435.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AVG4
      Conserved Domains (3) summary
      pfam05783
      Location:29 → 462
      DLIC; Dynein light intermediate chain (DLIC)
      pfam13238
      Location:56 → 178
      AAA_18; AAA domain
      cl21455
      Location:217 → 287
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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