ccl25b chemokine (C-C motif) ligand 25b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccl25bprovided by ZNC
Official Full Name: chemokine (C-C motif) ligand 25bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-110222-2
See related: Ensembl:ENSDARG00000070873 AllianceGenome:ZFIN:ZDB-GENE-110222-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables chemokine activity. Acts upstream of or within lymphoid lineage cell migration into thymus; regulation of hematopoietic stem cell migration; and regulation of hematopoietic stem cell proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blood vessel; head; hematopoietic system; immune system; and spinal cord. Orthologous to human CCL25 (C-C motif chemokine ligand 25). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (6261679..6265717, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (6264424..6268462, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified and cloned the zebrafish orthologues of CCL21 and CCL25; CCL21 was expressed in the craniofacial region, pharynx, and blood vessels in embryos. In adult fish, CCL21 transcripts were located in the kidney, spinal cord, and blood cells.
Title: Cloning, expression and characterization of CCL21 and CCL25 chemokines in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lymphoid lineage cell migration into thymus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of hematopoietic stem cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-C motif chemokine 25b

Names: CCL-chr11a; Dr11_WGA839_1_159228; ccl21; chemokine CCL-C11a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001200035.1 → NP_001186964.1 C-C motif chemokine 25b precursor

Status: VALIDATED

Source sequence(s)

BC133887, EH435143, EH555075

UniProtKB/TrEMBL

A0A8M1NXL4, F1QBE9

Related

ENSDARP00000095178.3, ENSDART00000104405.5

Conserved Domains (1) summary

pfam00048
Location:32 → 96

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like