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    Slc22a7 solute carrier family 22 member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89776, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc22a7provided by RGD
    Official Full Name
    solute carrier family 22 member 7provided by RGD
    Primary source
    RGD:621699
    See related
    Ensembl:ENSRNOG00000018420 AllianceGenome:RGD:621699
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oat2; Livtr; rOAT2
    Summary
    Enables organic anion transmembrane transporter activity. Involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Orthologous to human SLC22A7 (solute carrier family 22 member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 159.8) and Kidney (RPKM 85.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc22a7 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22044672..22052051)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14547073..14554354)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16925321..16931119)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene tau tubulin kinase 1 Neighboring gene cysteine-rich protein 3 Neighboring gene zinc finger protein 318 Neighboring gene small nucleolar RNA, H/ACA box 38 Neighboring gene uncharacterized LOC120094785

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats. Babelova A, et al. J Diabetes Res, 2015. PMID 25710042, Free PMC Article
    2. Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression. Chen C, et al. Mol Pharmacol, 2007 Apr. PMID 17244698
    3. Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen. Morita N, et al. Drug Metab Dispos, 2005 Aug. PMID 15900017
    4. Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. Morita N, et al. J Pharmacol Exp Ther, 2001 Sep. PMID 11504818
    5. Molecular cloning and characterization of a novel liver-specific transport protein. Simonson GD, et al. J Cell Sci, 1994 Apr. PMID 8056831

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine
      Title: Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.
    2. strongly decreased expression of Oat2 and other transporters in female diabetic ZSF1 rats could possibly impair renal drug excretion, for example, of furosemide
      Title: Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.
    3. Expression of rat OAT2 in HEK (human embryonic kidney)-293 cells stimulates accumulation of the zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from rat.
      Title: OAT2 catalyses efflux of glutamate and uptake of orotic acid.
    4. Oat2 mRNA expression was also highest in kidney rather than in liver. Considerably higher Oat2 levels were seen in female kidney as compared with male.
      Title: Gender-specific and developmental influences on the expression of rat organic anion transporters.
    5. In the zona glomerulosa and outer zona fasciculata. Oatp1-3 and OCT2 may be important for endocrine function of rat adrenocortical cells.
      Title: Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression.
    6. OAT2 in rat kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation
      Title: Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones.
    7. induction of Oatp2 expression in liver of fasted mice may be caused by activation of the cAMP-dependent signaling pathway, with the CRE site (-1808/-1804) and CREB being the cis- and trans-acting factors mediating the induction, respectively
      Title: Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-ketoglutarate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-ketoglutarate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables prostaglandin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in alpha-ketoglutarate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic anion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in prostaglandin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to stilbenoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 7
    Names
    Liver-specific transporter
    novel liver transporter
    organic anion transporter 2
    solute carrier family 22 (organic anion transporter), member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053537.2 → NP_445989.2  solute carrier family 22 member 7

      See identical proteins and their annotated locations for NP_445989.2

      Status: PROVISIONAL

      Source sequence(s)
      AY816233
      UniProtKB/Swiss-Prot
      Q5RLM2, Q63314
      UniProtKB/TrEMBL
      A6JIQ9
      Related
      ENSRNOP00000025094.3, ENSRNOT00000025094.6
      Conserved Domains (2) summary
      cd06174
      Location:144 → 511
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 521
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22044672..22052051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084305.2 → XP_038940233.1  solute carrier family 22 member 7 isoform X2

      Conserved Domains (1) summary
      TIGR00898
      Location:1 → 336
      2A0119; cation transport protein

    2. XM_039084304.2 → XP_038940232.1  solute carrier family 22 member 7 isoform X1

      Conserved Domains (1) summary
      TIGR00898
      Location:38 → 427
      2A0119; cation transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RLM2.1 GenPept UniProtKB/Swiss-Prot:Q5RLM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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