Ap1b1 adaptor related protein complex 1 subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ap1b1provided by RGD
Official Full Name: adaptor related protein complex 1 subunit beta 1provided by RGD
Primary source: RGD:2064
See related: Ensembl:ENSRNOG00000008786 AllianceGenome:RGD:2064
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adtb1
Summary: Predicted to enable protein kinase binding activity. Involved in clathrin coat assembly. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of clathrin coat. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 235.1), Brain (RPKM 218.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (84093529..84144835)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (79879482..79930778)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (85230652..85281806)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data indicate that the switch to JNK/AP-1 activation preserves HI-induced TNF-alpha expression and thereby might contribute to the neuroprotective effect of TAT-NBD possibly through a TNF-R2 dependent mechanism.
Title: Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia.
Results suggest that 10-day calorie restriction can attenuate the altered signal transduction for inflammatory processes which is mediated through reactive species-induced NF-kB and AP-1 in aged kidney.
Title: Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney.
results indicate that AP-1 could control MMP-3 induction in brain astrocytes and that its regulation through specific AP-1 elements could be exploited in the treatment of brain pathologies in which increased expression of MMP-3 plays crucial roles
Title: Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements.
Ramiprilat exerts direct, bradykinin-receptor independent effects on cardiomyocytes that improve cellular function without a corresponding effect on AP-1 activation or induction of AP-1 dependent effects.
Title: Direct effects of the angiotensin-converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables clathrin binding	IC Inferred by Curator more info	PubMed
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin coat assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
part_of clathrin coat	IC Inferred by Curator more info	PubMed
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AP-1 complex subunit beta-1

Names: adaptor-related protein complex 1, beta 1 subunit; adaptor-related protein complex AP-1 beta 1 subunit; beta-adaptin 1; clathrin assembly protein complex 1 beta large chain; golgi adaptor HA1/AP1 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308298.1 → NP_001295227.1 AP-1 complex subunit beta-1

See identical proteins and their annotated locations for NP_001295227.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P52303

UniProtKB/TrEMBL

A0A0G2K2V2, A6IKJ5

Related

ENSRNOP00000072388.2, ENSRNOT00000089866.2

Conserved Domains (5) summary

smart00809
Location:729 → 829

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:838 → 948

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region

pfam12717
Location:99 → 268

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

84093529..84144835

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273010.1 → XP_063129080.1 AP-1 complex subunit beta-1 isoform X2

UniProtKB/Swiss-Prot

P52303

UniProtKB/TrEMBL

A6IKJ6, G3V9N8
XM_063273009.1 → XP_063129079.1 AP-1 complex subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P52303

UniProtKB/TrEMBL

A0A0G2K2V2, A6IKJ5
XM_063273008.1 → XP_063129078.1 AP-1 complex subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P52303

UniProtKB/TrEMBL

A0A0G2K2V2, A6IKJ5
XM_039091797.2 → XP_038947725.1 AP-1 complex subunit beta-1 isoform X2

UniProtKB/Swiss-Prot

P52303

UniProtKB/TrEMBL

A6IKJ6, G3V9N8

Related

ENSRNOP00000054218.5

Conserved Domains (4) summary

smart00809
Location:722 → 822

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:831 → 941

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_063273011.1 → XP_063129081.1 AP-1 complex subunit beta-1 isoform X2

UniProtKB/Swiss-Prot

P52303

UniProtKB/TrEMBL

A6IKJ6, G3V9N8