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    Klhdc3 kelch domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363192, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Klhdc3provided by RGD
    Official Full Name
    kelch domain containing 3provided by RGD
    Primary source
    RGD:1307105
    See related
    Ensembl:ENSRNOG00000017495 AllianceGenome:RGD:1307105
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHDC3 (kelch domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 532.8), Testes (RPKM 441.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhdc3 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21799870..21806337)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14302345..14308736)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16612429..16618761)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glycine N-methyltransferase Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene male-enhanced antigen 1 Neighboring gene ribosomal RNA processing 36 Neighboring gene cullin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. Ohinata Y, et al. FEBS Lett, 2003 Feb 27. PMID 12606021
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012203.1 → NP_001012203.1  kelch domain-containing protein 3

      See identical proteins and their annotated locations for NP_001012203.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079035
      UniProtKB/Swiss-Prot
      Q6AYI2
      UniProtKB/TrEMBL
      A0A8I5ZJH5, A6JIP1
      Related
      ENSRNOP00000023979.4, ENSRNOT00000023979.7
      Conserved Domains (3) summary
      PLN02153
      Location:74 → 318
      PLN02153; epithiospecifier protein
      sd00038
      Location:128 → 173
      Kelch; KELCH repeat [structural motif]
      pfam13964
      Location:14 → 61
      Kelch_6; Kelch motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21799870..21806337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244542.5 → XP_006244604.1  kelch domain-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006244604.1

      UniProtKB/Swiss-Prot
      Q6AYI2
      UniProtKB/TrEMBL
      A0A8I5ZJH5, A6JIP1
      Conserved Domains (3) summary
      PLN02153
      Location:74 → 318
      PLN02153; epithiospecifier protein
      sd00038
      Location:128 → 173
      Kelch; KELCH repeat [structural motif]
      pfam13964
      Location:14 → 61
      Kelch_6; Kelch motif

    2. XM_039083822.2 → XP_038939750.1  kelch domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJH5
      Conserved Domains (3) summary
      PLN02153
      Location:74 → 318
      PLN02153; epithiospecifier protein
      sd00038
      Location:128 → 173
      Kelch; KELCH repeat [structural motif]
      pfam13964
      Location:14 → 61
      Kelch_6; Kelch motif

    3. XM_063267358.1 → XP_063123428.1  kelch domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJH5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYI2.1 GenPept UniProtKB/Swiss-Prot:Q6AYI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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