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    Ltbp1 latent transforming growth factor beta binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59107, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ltbp1provided by RGD
    Official Full Name
    latent transforming growth factor beta binding protein 1provided by RGD
    Primary source
    RGD:68379
    See related
    Ensembl:ENSRNOG00000033090 AllianceGenome:RGD:68379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microfibril binding activity and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 310.7), Lung (RPKM 206.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ltbp1 in Genome Data Viewer
    Location:
    6q13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (25781625..26177346, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (20029629..20425339, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (21203502..21600441, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 98, member A Neighboring gene RAS guanyl releasing protein 3 Neighboring gene ribosomal protein L32, pseudogene 18 Neighboring gene uncharacterized LOC120103479 Neighboring gene 40S ribosomal protein S18 pseudogene Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor-beta binding protein-1 (LTBP-1) mRNA expression in osteoblastic cells. Kwok S, et al. J Cell Biochem, 2005 Aug 1. PMID 15880704
    2. The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3). Maeda S, et al. Calcif Tissue Int, 2002 Jan. PMID 11907708
    3. Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. Zhu Y, et al. Neuroscience, 2001. PMID 11720783
    4. Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. Pedrozo HA, et al. J Cell Biochem, 1999 Jan 1. PMID 10025676
    5. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Roth-Eichhorn S, et al. Hepatology, 1998 Dec. PMID 9828223

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LTBP-1 but not TGF-beta1 is induced by PDGF-BB and TGF-beta1 autoinduction does not affect the expression of LTBP-beta1
      Title: PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line.
    2. Mesangial expression of LTBP-1 and fibrillin-1 is induced early in experimental nephritis and LTBP-1 and fibrillin-1 are partially colocalized in the nephritic glomerulus.
      Title: Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis.
    3. fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions
      Title: Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.
    4. observations suggest that latent transforming growth factor-beta binding protein-1 plays a critical role in intimal thickening of diabetic artery through the acceleration of smooth muscle cell migration via integrin-beta(3)
      Title: Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfibril binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfibril binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfibril binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor ligand inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor ligand inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to parathyroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of TGFbeta in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sequestering of TGFbeta in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sequestering of TGFbeta in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of large latent transforming growth factor-beta complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microfibril IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microfibril ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    latent-transforming growth factor beta-binding protein 1
    Names
    LTBP-1
    LanC (bacterial lantibiotic synthetase component C)-like 1
    TGF-beta-1-BP-1
    transforming growth factor beta-1-binding protein 1
    transforming growth factor beta-1-masking protein large subunit
    transforming growth factor-beta (TGF-beta) masking protein large subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021587.2 → NP_067598.2  latent-transforming growth factor beta-binding protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q00918
      UniProtKB/TrEMBL
      A6H9X2, D3ZAA3
      Related
      ENSRNOP00000040099.3, ENSRNOT00000047674.5
      Conserved Domains (6) summary
      smart00179
      Location:1194 → 1235
      EGF_CA; Calcium-binding EGF-like domain
      PHA03247
      Location:703 → 860
      PHA03247; large tegument protein UL36; Provisional
      cd00054
      Location:990 → 1023
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:907 → 947
      EGF_CA; Calcium-binding EGF domain
      pfam00683
      Location:681 → 722
      TB; TB domain
      pfam12662
      Location:888 → 910
      cEGF; Complement Clr-like EGF-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      25781625..26177346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262385.1 → XP_063118455.1  latent-transforming growth factor beta-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q00918
      UniProtKB/TrEMBL
      A0A8I6AA33

    2. XM_063262388.1 → XP_063118458.1  latent-transforming growth factor beta-binding protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q00918

    3. XM_063262387.1 → XP_063118457.1  latent-transforming growth factor beta-binding protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q00918
      UniProtKB/TrEMBL
      A0A8I5Y739

    4. XM_063262386.1 → XP_063118456.1  latent-transforming growth factor beta-binding protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q00918

    5. XM_063262389.1 → XP_063118459.1  latent-transforming growth factor beta-binding protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q00918

    6. XM_063262390.1 → XP_063118460.1  latent-transforming growth factor beta-binding protein 1 isoform X6

    7. XM_063262393.1 → XP_063118463.1  latent-transforming growth factor beta-binding protein 1 isoform X9

    8. XM_063262392.1 → XP_063118462.1  latent-transforming growth factor beta-binding protein 1 isoform X8

    9. XM_063262391.1 → XP_063118461.1  latent-transforming growth factor beta-binding protein 1 isoform X7

      UniProtKB/Swiss-Prot
      Q00918
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00918.1 GenPept UniProtKB/Swiss-Prot:Q00918

    Gene LinkOut

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