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    Skap2 src kinase associated phosphoprotein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 155183, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Skap2provided by RGD
    Official Full Name
    src kinase associated phosphoprotein 2provided by RGD
    Primary source
    RGD:620159
    See related
    Ensembl:ENSRNOG00000012228 AllianceGenome:RGD:620159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Scap2; Scap55r
    Summary
    Predicted to be involved in B cell activation. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human SKAP2 (src kinase associated phosphoprotein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 296.6), Spleen (RPKM 224.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Skap2 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (82281221..82431664, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (80948832..81100900, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (81816778..81968832, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102273 Neighboring gene uncharacterized LOC120102274 Neighboring gene uncharacterized LOC134486768 Neighboring gene uncharacterized LOC102550087 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene uncharacterized LOC120102275

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Curtis DJ, et al. Exp Hematol, 2000 Nov. PMID 11063873
    2. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. Kirchgessner H, et al. J Exp Med, 2001 Jun 4. PMID 11390434, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    src kinase-associated phosphoprotein 2
    Names
    SKAP-55HOM
    SKAP-HOM
    SKAP55 homolog
    SKAP55-HOM
    src family-associated phosphoprotein 2
    src kinase-associated phosphoprotein 55-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130413.1 → NP_569097.1  src kinase-associated phosphoprotein 2

      See identical proteins and their annotated locations for NP_569097.1

      Status: PROVISIONAL

      Source sequence(s)
      AF302132
      UniProtKB/Swiss-Prot
      Q920G0
      UniProtKB/TrEMBL
      A0A8I6A1S5, A6K0P7
      Related
      ENSRNOP00000016608.2, ENSRNOT00000016608.3
      Conserved Domains (2) summary
      cd13381
      Location:117 → 222
      PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
      cl17036
      Location:300 → 352
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      82281221..82431664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236477.5 → XP_006236539.1  src kinase-associated phosphoprotein 2 isoform X1

      See identical proteins and their annotated locations for XP_006236539.1

      UniProtKB/Swiss-Prot
      Q920G0
      UniProtKB/TrEMBL
      A0A8I6A1S5, A6K0P7
      Conserved Domains (2) summary
      cd13381
      Location:117 → 222
      PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
      cl17036
      Location:300 → 352
      SH3; Src Homology 3 domain superfamily

    2. XM_006236478.5 → XP_006236540.1  src kinase-associated phosphoprotein 2 isoform X1

      See identical proteins and their annotated locations for XP_006236540.1

      UniProtKB/Swiss-Prot
      Q920G0
      UniProtKB/TrEMBL
      A0A8I6A1S5, A6K0P7
      Conserved Domains (2) summary
      cd13381
      Location:117 → 222
      PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
      cl17036
      Location:300 → 352
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920G0.1 GenPept UniProtKB/Swiss-Prot:Q920G0

    Gene LinkOut

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