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    Zfp9 zinc finger protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 22750, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp9provided by MGI
    Official Full Name
    zinc finger protein 9provided by MGI
    Primary source
    MGI:MGI:99210
    See related
    Ensembl:ENSMUSG00000072623 AllianceGenome:MGI:99210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp-9; Krox-4; mszf79-2; 1810048F22Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in branchial arch; early conceptus; and genitourinary system. Orthologous to human ZNF25 (zinc finger protein 25). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 10.0), CNS E18 (RPKM 5.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp9 in Genome Data Viewer
    Location:
    6 F1; 6 55.86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118438911..118456922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118461950..118479961, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene BMS1, ribosome biogenesis factor Neighboring gene zinc finger protein 248 Neighboring gene zinc finger protein 248 pseudogene Neighboring gene ankyrin repeat domain 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
    2. Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Fairbridge NA, et al. Birth Defects Res A Clin Mol Teratol, 2010 Aug. PMID 20589882
    3. Decidualisation and placentation defects are a major cause of age-related reproductive decline. Woods L, et al. Nat Commun, 2017 Sep 5. PMID 28874785, Free PMC Article
    4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    5. Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Sultana DA, et al. Blood, 2009 Mar 26. PMID 19164599, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011763.2 → NP_035893.1  zinc finger protein 25

      See identical proteins and their annotated locations for NP_035893.1

      Status: VALIDATED

      Source sequence(s)
      AC140192, AK029052, BY132524
      Consensus CDS
      CCDS51885.1
      UniProtKB/TrEMBL
      Q8BIS1
      Related
      ENSMUSP00000123810.2, ENSMUST00000161170.2
      Conserved Domains (5) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:254 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:270 → 295
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      118438911..118456922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241293.2 → XP_011239595.1  zinc finger protein 25 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:249 → 404
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:181 → 206
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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