Anp32e acidic nuclear phosphoprotein 32 family member E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anp32eprovided by MGI
Official Full Name: acidic nuclear phosphoprotein 32 family member Eprovided by MGI
Primary source: MGI:MGI:1913721
See related: Ensembl:ENSMUSG00000015749 AllianceGenome:MGI:1913721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CPD1; LANPL; LANP-L; mLANP-L; 2810018A15Rik
Summary: Enables phosphatase inhibitor activity. Predicted to be involved in histone exchange and regulation of apoptotic process. Predicted to act upstream of or within chromatin organization. Located in cytoplasmic vesicle and nucleus. Is expressed in brain; liver; retina layer; and skeletal muscle. Orthologous to human ANP32E (acidic nuclear phosphoprotein 32 family member E). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 136.9), liver E14 (RPKM 55.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 41.59 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95836557..95854699)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95929245..95947387)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anp32e promotes renal interstitial fibrosis by upregulating the expression of fibrosis-related proteins.
Title: Anp32e promotes renal interstitial fibrosis by upregulating the expression of fibrosis-related proteins.
Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5' UTR rG4 unwinding and Anp32e translation.
Title: Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5' UTR rG4 unwinding and Anp32e translation.
The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons.
Title: The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons.
Genome-wide chromatin accessibility is restricted by ANP32E.
Title: Genome-wide chromatin accessibility is restricted by ANP32E.
The data also suggest that H2A.Z restricts transcription, which is moderated by ANP32e at the promoter and gene bodies of expressed genes. Thus, ANP32e, through inhibition of PP2A, is required for nucleosomal inclusion of H2A.Z and the regulation of gene expression
Title: Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A.
ANP32E gene mutations do not result in obvious motor activity defects.
Title: Targeted ANP32E mutant mice do not demonstrate obvious movement defects.
combined deletion of Anp32a and Anp32e also resulted in a viable and apparently healthy mouse. SIGNIFICANCE: These results provide evidence that significant functional redundancy exists among Anp32 family members
Title: Generation and characterization of the Anp32e-deficient mouse.
Cpd-1 null mice are viable and fertile, but display a subtle neurological clasping phenotype and mild motor deficits.
Title: Cpd-1 null mice display a subtle neurological phenotype.
This study propose that Anp32e/Cpd1 mediates synaptogenesis process by modulating Protein Phosphatase 2A activity.
Title: Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234759

AI326868 (e-PCR)
- UniSTS:159139

RH135842 (e-PCR)
- UniSTS:209840

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone chaperone activity	ISO Inferred from Sequence Orthology more info
enables phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Swr1 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member E

Names: LANP-like protein; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; cerebellar postnatal development protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253757.1 → NP_001240686.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 2

See identical proteins and their annotated locations for NP_001240686.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC092855, AI613710, AK147888, AK159446, BY270013, CF952181

Consensus CDS

CCDS57238.1

UniProtKB/Swiss-Prot

P97822

UniProtKB/TrEMBL

Q3TX26

Related

ENSMUSP00000015893.7, ENSMUST00000015893.13

Conserved Domains (4) summary

cd00116
Location:16 → 146

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:88 → 130

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:65 → 125

LRR_8; Leucine rich repeat
NM_001253758.1 → NP_001240687.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC092855, AI613710

Consensus CDS

CCDS57239.1

UniProtKB/TrEMBL

E9Q5H9

Related

ENSMUSP00000130599.2, ENSMUST00000171368.8
NM_023210.4 → NP_075699.3 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1

See identical proteins and their annotated locations for NP_075699.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI613710, AK049647, AK159446, BY254191

Consensus CDS

CCDS17626.1

UniProtKB/Swiss-Prot

E9Q5H9, P97822, Q3TH89, Q3TX26, Q8BPF8, Q8C2L4, Q8C7Q8, Q9CZD2

Related

ENSMUSP00000128483.2, ENSMUST00000165307.8

Conserved Domains (4) summary

cd00116
Location:16 → 146

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:88 → 130

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:65 → 125

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

95836557..95854699

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240193.2 → XP_011238495.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

Conserved Domains (2) summary

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam14580
Location:34 → 113

LRR_9; Leucine-rich repeat