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    SARK Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829175, updated on 15-Oct-2023

    Summary

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    Gene symbol
    SARK
    Gene description
    Leucine-rich repeat protein kinase family protein
    Primary source
    Araport:AT4G30520
    Locus tag
    AT4G30520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17I23.140; F17I23_140; SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE
    Summary
    Encodes SARK (SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE). Regulates leaf senescence through synergistic actions of auxin and ethylene.
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    Genomic context

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    See SARK in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (14907942..14911446, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein (DUF788) Neighboring gene autophagy 18 B-like protein Neighboring gene miscRNA Neighboring gene Class I glutamine amidotransferase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis. Xiao D, et al. Plant Physiol, 2015 Oct. PMID 26304848, Free PMC Article
    2. A soybean dual-specificity kinase, GmSARK, and its Arabidopsis homolog, AtSARK, regulate leaf senescence through synergistic actions of auxin and ethylene. Xu F, et al. Plant Physiol, 2011 Dec. PMID 22034630, Free PMC Article
    3. A group of receptor kinases are essential for CLAVATA signalling to maintain stem cell homeostasis. Hu C, et al. Nat Plants, 2018 Apr. PMID 29581511
    4. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article
    5. An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Smakowska-Luzan E, et al. Nature, 2018 Jan 18. PMID 29320478, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SSPP (At5g02760)directly interacts with the cytoplasmic domain of SARK (At4g30520)and negatively regulates leaf senescence in Arabidopsis.
      Title: SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis.
    2. A kinase assay on recombinant catalytic domains of GmSARK and AtSARK revealed that these two leucine-rich repeat-receptor-like protein kinases autophosphorylate on both serine/threonine and tyrosine residues.
      Title: A soybean dual-specificity kinase, GmSARK, and its Arabidopsis homolog, AtSARK, regulate leaf senescence through synergistic actions of auxin and ethylene.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119198.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables coreceptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anther development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of meristem cells IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_194781.2
    • Leucine-rich repeat protein kinase family protein; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT2G23950.1); Has 174451 Blast hits to 119898 proteins in 4449 species: Archae - 119; Bacteria - 15134; Metazoa - 46216; Fungi - 8564; Plants - 84893; Viruses - 425; Other Eukaryotes - 19100 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14907942..14911446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119198.5 → NP_194781.2  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194781.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYT3, Q9M0A8
      UniProtKB/TrEMBL
      A0A178UW81, A0A5S9XY74, A0A654FUA6
      Conserved Domains (3) summary
      PLN00113
      Location:15 → 191
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:103 → 126
      LRR_RI; leucine-rich repeat [structural motif]
      cl21453
      Location:309 → 575
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYT3.1

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