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    mcm2.L minichromosome maintenance complex component 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 380451, updated on 2-May-2024

    Summary

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    Official Symbol
    mcm2.L
    Official Full Name
    minichromosome maintenance complex component 2 L homeolog
    Primary source
    Xenbase:XB-GENE-999979
    Locus tag
    XELAEV_18023987mg
    See related
    EnsemblRapid:ENSXLAG00005025706
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    bm28; mcm2; ccnl1; cdc19; cdcl1; mitotin
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    Genomic context

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    See mcm2.L in Genome Data Viewer
    Location:
    chromosome: 4L
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (134636854..134667849)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (129389999..129421497)

    Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein, adipocyte asscociated 1 L homeolog Neighboring gene 2-aminoethanethiol dioxygenase-like Neighboring gene uncharacterized LOC108713580 Neighboring gene ankyrin repeat and BTB (POZ) domain containing 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. Gambus A, et al. J Biol Chem, 2011 Apr 1. PMID 21282109, Free PMC Article
    2. Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex. Pereverzeva I, et al. Mol Cell Biol, 2000 May. PMID 10779356, Free PMC Article
    3. Identification of two Xenopus laevis genes, xMCM2 and xCDC46, with sequence homology to MCM genes involved in DNA replication. Miyake S, et al. Gene, 1996 Oct 10. PMID 8917078
    4. Xenopus CDC7/DRF1 complex is required for the initiation of DNA replication. Silva T, et al. J Biol Chem, 2006 Apr 28. PMID 16507577
    5. Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Takahashi TS, et al. Genes Dev, 2005 Oct 1. PMID 16204181, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
      Title: RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks.
    2. Mcm2-7 associate with Cdc45 and GINS to form a relatively stable CMG (Cdc45-MCM-GINS) complex.
      Title: MCM2-7 form double hexamers at licensed origins in Xenopus egg extract.
    3. ATM and ATR phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts
      Title: Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses.
    4. MCM2-7 is the replicative helicase, dispensable for chromatin loading and pre-replicative complex (pre-RC) assembly, but required for origin unwinding during DNA replication
      Title: The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC53486

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA unwinding involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA unwinding involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via break-induced replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within premeiotic DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MCM complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor mcm2
    Names
    BM28-homolog
    minichromosome maintenance protein 2
    p112
    xMCM2
    NP_001080759.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087290.2 → NP_001080759.1  DNA replication licensing factor mcm2

      See identical proteins and their annotated locations for NP_001080759.1

      Status: PROVISIONAL

      Source sequence(s)
      U44047
      UniProtKB/Swiss-Prot
      O42588, P55861, Q7ZX05
      UniProtKB/TrEMBL
      A0A974HQ43
      Related
      ENSXLAP00005076480.1, ENSXLAT00005078070.1
      Conserved Domains (4) summary
      smart00350
      Location:276 → 785
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:56 → 167
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:183 → 295
      MCM_N; MCM N-terminal domain
      cl21455
      Location:503 → 642
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      134636854..134667849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55861.2 GenPept UniProtKB/Swiss-Prot:P55861

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials