mcm4.L minichromosome maintenance complex component 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mcm4.L
Official Full Name: minichromosome maintenance complex component 4 L homeolog
Primary source: Xenbase:XB-GENE-1011486
Locus tag: XELAEV_18031991mg
See related: EnsemblRapid:ENSXLAG00005035505
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mcm4; cdc21; mcm4-a; mcm4-b; mcm4.S
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 6L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (120802531..120813632)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (113684087..113695190)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA strand elongation involved in DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA unwinding involved in DNA replication	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA unwinding involved in DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via break-induced replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within premeiotic DNA replication	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CMG complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IEA Inferred from Electronic Annotation more info
part_of MCM complex	IPI Inferred from Physical Interaction more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA replication licensing factor mcm4-B

Names: CDC21 homolog-B; P1-CDC21-B; minichromosome maintenance complex component 4 S homeolog; minichromosome maintenance protein 4-B; xMCM4-B

NP_001081448.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087979.1 → NP_001081448.1 DNA replication licensing factor mcm4-B

See identical proteins and their annotated locations for NP_001081448.1

Status: PROVISIONAL

Source sequence(s)

U29178

UniProtKB/Swiss-Prot

P30664, Q6GQ77, Q91679

UniProtKB/TrEMBL

A0A974HG97

Related

ENSXLAP00005106268.1, ENSXLAT00005108352.1

Conserved Domains (3) summary

smart00350
Location:267 → 770

MCM; minichromosome maintenance proteins

pfam14551
Location:165 → 287

MCM_N; MCM N-terminal domain

cl21455
Location:505 → 644

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases