setd7 SET domain containing 7, histone lysine methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: setd7provided by ZNC
Official Full Name: SET domain containing 7, histone lysine methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-156
See related: Ensembl:ENSDARG00000038858 AllianceGenome:ZFIN:ZDB-GENE-040718-156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: set7; zgc:92330; zgc:101860
Summary: Predicted to enable histone-lysine N-methyltransferase activity. Acts upstream of or within heart morphogenesis. Predicted to be located in chromosome and nucleus. Is expressed in heart; heart tube; lens; and somite. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (46199941..46213584, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (47212649..47226295, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine monomethylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase SETD7

Names: SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7

NP_001002456.1

EC 2.1.1.364

XP_005169666.1

EC 2.1.1.364

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002456.1 → NP_001002456.1 histone-lysine N-methyltransferase SETD7

See identical proteins and their annotated locations for NP_001002456.1

Status: PROVISIONAL

Source sequence(s)

BC076014

UniProtKB/Swiss-Prot

Q6DHG0

Related

ENSDARP00000056733.3, ENSDART00000056734.4

Conserved Domains (1) summary

pfam00856
Location:227 → 336

SET; SET domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

46199941..46213584 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005169609.3 → XP_005169666.1 histone-lysine N-methyltransferase SETD7 isoform X1

UniProtKB/TrEMBL

A0A8M2BGX6

Conserved Domains (1) summary

pfam00856
Location:110 → 219

SET; SET domain