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    cblb Cbl proto-oncogene B, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 556277, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cblbprovided by ZNC
    Official Full Name
    Cbl proto-oncogene B, E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-417
    See related
    Ensembl:ENSDARG00000015199 AllianceGenome:ZFIN:ZDB-GENE-030616-417
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CBL; Cas-Br-M; dZ25N23.1; si:dz25n23.1; si:dz39l02.2; si:busm1-25n23.1; si:busm1-39l02.2
    Summary
    Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and regulation of signaling. Predicted to be located in cytoplasm. Predicted to be active in membrane raft and plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See cblb in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (28587496..28731667)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (28700881..28844995)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911768 Neighboring gene BBX, HMG-box containing Neighboring gene uncharacterized LOC110440072 Neighboring gene uncharacterized LOC110440073 Neighboring gene uncharacterized LOC101883380 Neighboring gene uncharacterized LOC103911755 Neighboring gene activated leukocyte cell adhesion molecule a Neighboring gene si:ch211-103f14.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of immune responses by E3 ubiquitin-protein ligases. Fang N, et al. Curr Dir Autoimmun, 2002. PMID 11826757
    2. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase CBL-B
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence b
    ectopic retroviral transforming
    retroviral transforming sequence
    XP_001921961.4
    XP_021327977.1
    XP_021329887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      28587496..28731667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001921926.7 → XP_001921961.4  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/TrEMBL
      A0A8M1QR09, F1Q742
      Related
      ENSDARP00000033942.9, ENSDART00000030138.10
      Conserved Domains (5) summary
      cd09920
      Location:243 → 339
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:368 → 410
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:891 → 931
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:39 → 162
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:166 → 249
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394789.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      322222..385850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472302.1 → XP_021327977.1  E3 ubiquitin-protein ligase CBL-B isoform X2

      UniProtKB/TrEMBL
      A0A8M9PAD4
      Conserved Domains (2) summary
      pfam02262
      Location:39 → 162
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:166 → 184
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395290.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      112132..238155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474212.1 → XP_021329887.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/TrEMBL
      A0A8M9PFD0
      Conserved Domains (5) summary
      cd09920
      Location:243 → 339
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:891 → 931
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:39 → 162
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:166 → 249
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
      cd16709
      Location:349 → 414
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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