farsb phenylalanyl-tRNA synthetase subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: farsbprovided by ZNC
Official Full Name: phenylalanyl-tRNA synthetase subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021206-2
See related: Ensembl:ENSDARG00000016864 AllianceGenome:ZFIN:ZDB-GENE-021206-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb428; farsl; zgc:92055
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; musculature system; and nervous system. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (42264895..42283799, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (42308543..42327447, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
contributes_to phenylalanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylalanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phenylalanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phenylalanine--tRNA ligase beta subunit

Names: phenylalanyl-tRNA synthetase, beta subunit

NP_001007769.1

EC 6.1.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007768.1 → NP_001007769.1 phenylalanine--tRNA ligase beta subunit

See identical proteins and their annotated locations for NP_001007769.1

Status: PROVISIONAL

Source sequence(s)

BC085625

UniProtKB/TrEMBL

Q5RKM6

Related

ENSDARP00000007817.5, ENSDART00000015979.6

Conserved Domains (4) summary

smart00873
Location:120 → 281

B3_4; B3/4 domain

PLN02265
Location:1 → 590

PLN02265; probable phenylalanyl-tRNA synthetase beta chain

cd00769
Location:396 → 589

PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...

pfam03484
Location:314 → 376

B5; tRNA synthetase B5 domain