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    clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit [ Danio rerio (zebrafish) ]

    Gene ID: 553713, updated on 5-May-2024

    Summary

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    Official Symbol
    clppprovided by ZNC
    Official Full Name
    caseinolytic mitochondrial matrix peptidase proteolytic subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7860
    See related
    Ensembl:ENSDARG00000020679 AllianceGenome:ZFIN:ZDB-GENE-030131-7860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj37a05; wu:fj37a05; zgc:112333; si:dkey-204f11.65
    Summary
    Predicted to enable ATP-dependent peptidase activity; ATPase binding activity; and serine-type endopeptidase activity. Predicted to be involved in protein quality control for misfolded or incompletely synthesized proteins. Predicted to act upstream of or within proteolysis. Predicted to be part of endopeptidase Clp complex. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See clpp in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (34129510..34136372, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (34000002..34006864, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy variable 3-30 Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene si:dkey-204f11.64 Neighboring gene coactivator-associated arginine methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Chen D, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30916346, Free PMC Article
    2. BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Shi W, et al. J Immunol, 2019 Nov 1. PMID 31562209
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112333

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP-dependent peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of endopeptidase Clp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Names
    ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog
    caseinolytic protease, ATP-dependent, proteolytic subunit homolog
    NP_001018520.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020684.1 → NP_001018520.1  ATP-dependent Clp protease proteolytic subunit, mitochondrial

      See identical proteins and their annotated locations for NP_001018520.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095769
      UniProtKB/TrEMBL
      Q502B9
      Related
      ENSDARP00000147729.1, ENSDART00000186125.1
      Conserved Domains (1) summary
      PRK00277
      Location:27 → 222
      clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      34129510..34136372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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