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    Hoxd8 homeobox D8 [ Mus musculus (house mouse) ]

    Gene ID: 15437, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hoxd8provided by MGI
    Official Full Name
    homeobox D8provided by MGI
    Primary source
    MGI:MGI:96209
    See related
    Ensembl:ENSMUSG00000027102 AllianceGenome:MGI:96209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hox-4.3; Hox-5.4; 4921540P06Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; hindlimb bud; limb; and nervous system. Orthologous to human HOXD8 (homeobox D8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 25.2), ovary adult (RPKM 21.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hoxd8 in Genome Data Viewer
    Location:
    2 C3; 2 44.13 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (74534973..74538277)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (74704615..74707933)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene homeobox D11 Neighboring gene STARR-seq mESC enhancer starr_04854 Neighboring gene homeobox D10 Neighboring gene homeobox D9 Neighboring gene predicted gene, 38462 Neighboring gene homeobox D3, opposite strand 1 Neighboring gene homeobox D3 Neighboring gene homeobox D4 Neighboring gene microRNA 10b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds. Jain K, et al. J Surg Res, 2008 Jul. PMID 18570930
    2. Sequence analysis of the homeobox-containing exon of the murine Hox-4.3 homeogene. Sadoul R, et al. Biochim Biophys Acta, 1991 Jun 13. PMID 1675873
    3. Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. Guerreiro I, et al. Elife, 2016 Aug 1. PMID 27476854, Free PMC Article
    4. Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene. Izpisùa-Belmonte JC, et al. Development, 1990 Nov. PMID 1982431
    5. Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken. Hintermann A, et al. Development, 2022 Jun 15. PMID 35770682, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression.
      Title: HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression.
    2. Prox1 and HoxD8 play important roles in the maturation and maintenance of lymphatic vessels.
      Title: Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
    3. Hoxd8 is increased in mid-gestational wounds compared with late-gestational control skin
      Title: Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Hox-D8
    Names
    homeo box D8
    homeobox protein Hox-4.3
    homeobox protein Hox-5.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290730.2 → NP_001277659.1  homeobox protein Hox-D8 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
      Source sequence(s)
      AL928644
      Consensus CDS
      CCDS71077.1
      UniProtKB/TrEMBL
      A2ASN1
      Related
      ENSMUSP00000088094.5, ENSMUST00000074721.6
      Conserved Domains (2) summary
      smart00389
      Location:194 → 250
      HOX; Homeodomain
      COG5576
      Location:139 → 271
      COG5576; Homeodomain-containing transcription factor [Transcription]

    2. NM_001290731.2 → NP_001277660.1  homeobox protein Hox-D8 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL928644
      Consensus CDS
      CCDS79809.1
      UniProtKB/TrEMBL
      F6W963
      Related
      ENSMUSP00000118904.3, ENSMUST00000151380.2
      Conserved Domains (1) summary
      pfam00046
      Location:17 → 69
      Homeobox; Homeobox domain

    3. NM_008276.4 → NP_032302.2  homeobox protein Hox-D8 isoform a

      See identical proteins and their annotated locations for NP_032302.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL928644
      Consensus CDS
      CCDS16143.1
      UniProtKB/Swiss-Prot
      A2ASN2, P23463
      Related
      ENSMUSP00000019749.4, ENSMUST00000019749.4
      Conserved Domains (2) summary
      COG5576
      Location:139 → 272
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:199 → 251
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      74534973..74538277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23463.4 GenPept UniProtKB/Swiss-Prot:P23463

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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