Tnmd tenomodulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnmdprovided by RGD
Official Full Name: tenomodulinprovided by RGD
Primary source: RGD:620938
See related: Ensembl:ENSRNOG00000060970 AllianceGenome:RGD:620938
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ChM1L
Summary: Involved in cellular response to BMP stimulus and tendon cell differentiation. Predicted to be located in nuclear envelope. Predicted to be integral component of membrane. Orthologous to human TNMD (tenomodulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 183.0), Spleen (RPKM 16.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (101350432..101365929)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (97057137..97072634)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (104684676..104700173)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanical stretch facilitates tenomodulin expression to induce tenocyte migration via MAPK signaling pathway.
Title: Mechanical stretch facilitates tenomodulin expression to induce tenocyte migration via MAPK signaling pathway.
Stretch-Induced Tenomodulin Expression Promotes Tenocyte Migration via F-Actin and Chromatin Remodeling.
Title: Stretch-Induced Tenomodulin Expression Promotes Tenocyte Migration via F-Actin and Chromatin Remodeling.
Study in Sprague-Dawley rats demonstrated that 10 Hz vertical vibration stimulated the anabolic effect of tenocytes and the stiffness of intact Achilles tendons by increasing the expression of TGF-beta1, which was followed by an increased expression of tenomodulin and type I collagen that then improved Achilles tendon stiffness via mechano-transduction.
Title: Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon.
Wnt/beta-catenin decreased Mkx and Tnmd expressions without suppressing Scx expression in Scx-programmed tendon progenitors.
Title: Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells.
Data show that chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.
Title: Identification of differentially expressed genes in mandibular condylar and tibial growth cartilages using laser microdissection and fluorescent differential display: chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.

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General gene information

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Markers

RH132574 (e-PCR)
- UniSTS:215857

1110017I01Rik (e-PCR), detects polymorphism
- UniSTS:265045

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to BMP stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in tendon cell differentiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tenomodulin

Names: chondromodulin-1-like protein; chondromodulin-I-like protein; myodulin; rChM1L; rTeM; teM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022290.1 → NP_071626.1 tenomodulin

See identical proteins and their annotated locations for NP_071626.1

Status: PROVISIONAL

Source sequence(s)

AF191769

UniProtKB/Swiss-Prot

Q9ESC2

UniProtKB/TrEMBL

A0A8I5Y566, A6IVD7

Related

ENSRNOP00000073972.1, ENSRNOT00000083229.2

Conserved Domains (1) summary

smart01039
Location:93 → 186

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer