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    Ptpn21 protein tyrosine phosphatase, non-receptor type 21 [ Mus musculus (house mouse) ]

    Gene ID: 24000, updated on 12-May-2024

    Summary

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    Official Symbol
    Ptpn21provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 21provided by MGI
    Primary source
    MGI:MGI:1344406
    See related
    Ensembl:ENSMUSG00000021009 AllianceGenome:MGI:1344406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTPD1; PTPRL10
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 9.4), ovary adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptpn21 in Genome Data Viewer
    Location:
    12 E; 12 49.88 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98643000..98703664, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98676741..98737613, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:99839121-99839422 Neighboring gene predicted gene, 25486 Neighboring gene STARR-seq mESC enhancer starr_32998 Neighboring gene spermatogenesis associated 7 Neighboring gene STARR-seq mESC enhancer starr_33000 Neighboring gene STARR-positive B cell enhancer ABC_E9861 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene echinoderm microtubule associated protein like 5 Neighboring gene predicted gene, 35463

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics. Ni F, et al. Cell Stem Cell, 2019 Apr 4. PMID 30880025, Free PMC Article
    2. Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. Carlucci A, et al. J Biol Chem, 2008 Apr 18. PMID 18223254
    3. PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport. Siddiqui N, et al. Nat Commun, 2019 Jun 19. PMID 31217419, Free PMC Article
    4. Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. Higashitsuji H, et al. Oncogene, 1995 Jan 19. PMID 7838537
    5. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Cardone L, et al. Mol Cell Biol, 2004 Jun. PMID 15143158, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ptpn21 maintains cellular mechanics, which is correlated with its important functions in Hematopoietic stem cell (HSC) niche retention and preservation of hematopoietic regeneration capacity.
      Title: Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
    2. Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
      Title: PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
    3. PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites
      Title: Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Homology

    Clone Names

    • MGC107492

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 21
    Names
    protein-tyrosine phosphatase PTP-RL10
    NP_001139671.1
    NP_036007.2
    XP_011242414.1
    XP_036013301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146199.1 → NP_001139671.1  tyrosine-protein phosphatase non-receptor type 21

      See identical proteins and their annotated locations for NP_001139671.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124516, AC159193, BC098500
      Consensus CDS
      CCDS26098.1
      UniProtKB/TrEMBL
      G5E8J4, Q4KML9
      Related
      ENSMUSP00000126975.2, ENSMUST00000170188.8
      Conserved Domains (6) summary
      smart00194
      Location:898 → 1168
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:24 → 222
      B41; Band 4.1 homologues
      cd00047
      Location:925 → 1168
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:217 → 307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:109 → 220
      FERM_M; FERM central domain
      pfam09379
      Location:27 → 90
      FERM_N; FERM N-terminal domain

    2. NM_011877.2 → NP_036007.2  tyrosine-protein phosphatase non-receptor type 21

      See identical proteins and their annotated locations for NP_036007.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124516, AC159193, BC098500
      Consensus CDS
      CCDS26098.1
      UniProtKB/TrEMBL
      G5E8J4, Q4KML9
      Related
      ENSMUSP00000082197.3, ENSMUST00000085116.4
      Conserved Domains (6) summary
      smart00194
      Location:898 → 1168
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:24 → 222
      B41; Band 4.1 homologues
      cd00047
      Location:925 → 1168
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:217 → 307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:109 → 220
      FERM_M; FERM central domain
      pfam09379
      Location:27 → 90
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      98643000..98703664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244112.4 → XP_011242414.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      UniProtKB/TrEMBL
      Q7TMG1
      Conserved Domains (1) summary
      cl28904
      Location:471 → 757
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_036157408.1 → XP_036013301.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      UniProtKB/TrEMBL
      Q7TMG1
      Conserved Domains (1) summary
      cl28904
      Location:471 → 757
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62136.1 GenPept UniProtKB/Swiss-Prot:Q62136

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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