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    Rbms1 RNA binding motif, single stranded interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56878, updated on 8-May-2024

    Summary

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    Official Symbol
    Rbms1provided by MGI
    Official Full Name
    RNA binding motif, single stranded interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1861774
    See related
    Ensembl:ENSMUSG00000026970 AllianceGenome:MGI:1861774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    YC1; MSSP-1; MSSP-2; MSSP-3; 2600014B10Rik
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to act upstream of or within DNA replication. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and immune system. Orthologous to human RBMS1 (RNA binding motif single stranded interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 26.0), ovary adult (RPKM 17.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbms1 in Genome Data Viewer
    Location:
    2 C1.2; 2 34.95 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60580537..60794224, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60750193..60963880, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene integrin beta 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:60555461-60555644 Neighboring gene STARR-seq mESC enhancer starr_04618 Neighboring gene predicted gene, 33436 Neighboring gene VISTA enhancer mm1564 Neighboring gene STARR-seq mESC enhancer starr_04621 Neighboring gene STARR-seq mESC enhancer starr_04622 Neighboring gene STARR-positive B cell enhancer ABC_E9002 Neighboring gene STARR-positive B cell enhancer ABC_E5923 Neighboring gene predicted gene, 50617 Neighboring gene predicted gene 13582 Neighboring gene predicted gene, 33647 Neighboring gene predicted gene, 39833

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA Binding Protein Rbms1 Enables Neuronal Differentiation and Radial Migration during Neocortical Development by Binding and Stabilizing the RNA Message for Efr3a. Habib K, et al. Mol Cells, 2022 Aug 31. PMID 35754370, Free PMC Article
    2. Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice. Nomura J, et al. Exp Cell Res, 2005 May 1. PMID 15817157
    3. Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice. Fujimoto M, et al. Genes Cells, 2001 Dec. PMID 11737267
    4. Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein. Fujimoto M, et al. Int J Oncol, 2000 Feb. PMID 10639566
    5. Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1. Yin M, et al. Mol Endocrinol, 2012 Jul. PMID 22593182, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
      Title: CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
    2. Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.
      Title: Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.
    3. study demonstrates that miR-383 functions as a positive regulator of E2 release in ovarian granulosa cells through inhibiting expression of RBMS1 and its downstream c-Myc
      Title: Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif, single-stranded-interacting protein 1
    Names
    single-stranded DNA-binding protein MSSP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141931.1 → NP_001135403.1  RNA-binding motif, single-stranded-interacting protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA175245, AK145897, AK147109, AK161102
      UniProtKB/TrEMBL
      Q3UKR8, Q3V0L4
      Conserved Domains (2) summary
      cd12470
      Location:53 → 138
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:139 → 224
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    2. NM_001141932.1 → NP_001135404.1  RNA-binding motif, single-stranded-interacting protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA175245, AK145897, AK161102
      Consensus CDS
      CCDS50590.1
      UniProtKB/TrEMBL
      E9PZ21, Q3TTX8
      Related
      ENSMUSP00000131306.2, ENSMUST00000164147.8
      Conserved Domains (2) summary
      cd12470
      Location:53 → 138
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:139 → 224
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    3. NM_020296.2 → NP_064692.2  RNA-binding motif, single-stranded-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_064692.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' UTR and 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA175245, AK147109, AK161102, BC016501
      Consensus CDS
      CCDS50591.1
      UniProtKB/Swiss-Prot
      Q3UI25, Q3UXU2, Q6PEU6, Q6PHC2, Q91W59, Q9WTK4
      UniProtKB/TrEMBL
      Q3UKR8, Q3V0L4
      Related
      ENSMUSP00000028347.7, ENSMUST00000028347.13
      Conserved Domains (2) summary
      cd12470
      Location:55 → 140
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:141 → 226
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      60580537..60794224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499940.2 → XP_006500003.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3TTX8
      Conserved Domains (2) summary
      cd12470
      Location:55 → 140
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:141 → 226
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    2. XM_030251908.1 → XP_030107768.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3UKR8, Q3V0L4
      Conserved Domains (2) summary
      cd12470
      Location:55 → 140
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:141 → 226
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    3. XM_017319146.1 → XP_017174635.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      Q3TTX8
      Conserved Domains (2) summary
      cd12470
      Location:55 → 140
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:141 → 226
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    4. XM_030251910.1 → XP_030107770.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      Q3UKR8, Q3V0L4
      Conserved Domains (2) summary
      cd12470
      Location:35 → 120
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:121 → 206
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    5. XM_006499942.3 → XP_006500005.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      Q3TTX8
      Conserved Domains (2) summary
      cd12470
      Location:35 → 120
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:121 → 206
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    6. XM_030251909.2 → XP_030107769.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UKR8, Q3V0L4
      Conserved Domains (2) summary
      cd12470
      Location:53 → 138
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:139 → 224
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    7. XM_030251907.2 → XP_030107767.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      Q3TTX8
      Conserved Domains (2) summary
      cd12470
      Location:53 → 138
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:139 → 224
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    8. XM_036162420.1 → XP_036018313.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3TTX8
      Conserved Domains (2) summary
      cd12470
      Location:45 → 130
      RRM1_MSSP1; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12473
      Location:131 → 215
      RRM2_MSSP1; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W59.1 GenPept UniProtKB/Swiss-Prot:Q91W59

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