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    Zranb2 zinc finger, RAN-binding domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 53861, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zranb2provided by MGI
    Official Full Name
    zinc finger, RAN-binding domain containing 2provided by MGI
    Primary source
    MGI:MGI:1858211
    See related
    Ensembl:ENSMUSG00000028180 AllianceGenome:MGI:1858211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zis; Zfp265; Znf265
    Summary
    Predicted to enable lipopolysaccharide binding activity. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Is expressed in genitourinary system and telencephalon. Orthologous to human ZRANB2 (zinc finger RANBP2-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 33.5), CNS E18 (RPKM 33.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zranb2 in Genome Data Viewer
    Location:
    3 H4; 3 81.29 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157239749..157254029)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (157534120..157548390)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09370 Neighboring gene predicted gene 5983 Neighboring gene STARR-seq mESC enhancer starr_09371 Neighboring gene RIKEN cDNA 4930592C13 gene Neighboring gene STARR-seq mESC enhancer starr_09372 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157228208-157228509 Neighboring gene microRNA 186 Neighboring gene STARR-seq mESC enhancer starr_09373 Neighboring gene STARR-seq mESC enhancer starr_09375 Neighboring gene prostaglandin E receptor 3 (subtype EP3) Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:157279973-157280264 Neighboring gene STARR-seq mESC enhancer starr_09378 Neighboring gene predicted gene 5550

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling. Ohte S, et al. J Cell Biochem, 2012 Mar. PMID 22021003
    2. ZRANB2: structural and functional insights into a novel splicing protein. Mangs AH, et al. Int J Biochem Cell Biol, 2008. PMID 17905639
    3. Expression pattern and splicing function of mouse ZNF265. Li J, et al. Neurochem Res, 2008 Mar. PMID 17805964
    4. Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA. Nguyen CD, et al. J Mol Biol, 2011 Mar 25. PMID 21256132
    5. Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. Adams DJ, et al. Cytogenet Cell Genet, 2000. PMID 10773668

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger Ran-binding domain-containing protein 2
    Names
    zinc finger protein 265
    zinc finger, splicing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355381.2 → NP_001342310.1  zinc finger Ran-binding domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC141480
      Related
      ENSMUSP00000029831.10, ENSMUST00000029831.16

    2. NM_001355386.2 → NP_001342315.1  zinc finger Ran-binding domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC141480
      Consensus CDS
      CCDS89715.1
      UniProtKB/TrEMBL
      D3Z4U0
      Related
      ENSMUSP00000101672.3, ENSMUST00000106057.8
      Conserved Domains (2) summary
      smart00547
      Location:67 → 91
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:13 → 34
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    3. NM_001410610.1 → NP_001397539.1  zinc finger Ran-binding domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC141480

    4. NM_001410611.1 → NP_001397540.1  zinc finger Ran-binding domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC141480

    5. NM_001410612.1 → NP_001397541.1  zinc finger Ran-binding domain-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC141480

    6. NM_001410613.1 → NP_001397542.1  zinc finger Ran-binding domain-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC141480

    7. NM_001410614.1 → NP_001397543.1  zinc finger Ran-binding domain-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC141480

    8. NM_001410615.1 → NP_001397544.1  zinc finger Ran-binding domain-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC141480

    9. NM_001410616.1 → NP_001397545.1  zinc finger Ran-binding domain-containing protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC141480

    10. NM_001410617.1 → NP_001397546.1  zinc finger Ran-binding domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC141480

    11. NM_001410618.1 → NP_001397547.1  zinc finger Ran-binding domain-containing protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC141480

    12. NM_001410619.1 → NP_001397548.1  zinc finger Ran-binding domain-containing protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC141480
      Related
      ENSMUSP00000101678.4, ENSMUST00000106063.6

    13. NM_017381.4 → NP_059077.1  zinc finger Ran-binding domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_059077.1

      Status: VALIDATED

      Source sequence(s)
      AC141480
      Consensus CDS
      CCDS51100.1
      UniProtKB/Swiss-Prot
      Q3TI29, Q3TLF5, Q3TUB7, Q3UD16, Q9R020
      UniProtKB/TrEMBL
      B2RRT9, D3Z4T9
      Related
      ENSMUSP00000101673.3, ENSMUST00000106058.8
      Conserved Domains (2) summary
      smart00547
      Location:67 → 91
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:13 → 34
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      157239749..157254029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319646.3 → XP_017175135.1  zinc finger Ran-binding domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      D3Z4U0
      Conserved Domains (2) summary
      smart00547
      Location:67 → 91
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:13 → 34
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R020.2 GenPept UniProtKB/Swiss-Prot:Q9R020

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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