otub1b OTU deubiquitinase, ubiquitin aldehyde binding 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: otub1bprovided by ZNC
Official Full Name: OTU deubiquitinase, ubiquitin aldehyde binding 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-204
See related: Ensembl:ENSDARG00000011462 AllianceGenome:ZFIN:ZDB-GENE-040718-204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: otub1; fa19h07; zgc:92839; wu:fa19h07
Summary: Predicted to enable thiol-dependent deubiquitinase and ubiquitin binding activity. Predicted to be involved in negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; and protein K48-linked deubiquitination. Predicted to act upstream of or within protein deubiquitination. Predicted to be active in nucleus. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24815812..24828869, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24544655..24557712, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi88b07.y1 (e-PCR)
- UniSTS:198155

fa19h07.s1 (e-PCR)
- UniSTS:202453

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin thioesterase OTUB1b

Names: OTU domain, ubiquitin aldehyde binding 1; OTU domain, ubiquitin aldehyde binding 1b

NP_001002500.2

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002500.2 → NP_001002500.2 ubiquitin thioesterase OTUB1b

Status: VALIDATED

Source sequence(s)

EH433266, EH460846

UniProtKB/TrEMBL

A0A8M1N0M6, F6P1A9

Related

ENSDARP00000006133.8, ENSDART00000005853.9

Conserved Domains (1) summary

pfam10275
Location:35 → 266

Peptidase_C65; Peptidase C65 Otubain