afg3l2 AFG3-like AAA ATPase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: afg3l2provided by ZNC
Official Full Name: AFG3-like AAA ATPase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-46
See related: Ensembl:ENSDARG00000062272 AllianceGenome:ZFIN:ZDB-GENE-070912-46
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-12e1.4
Summary: Predicted to enable ATP binding activity; peptidase activity; and zinc ion binding activity. Predicted to be involved in mitochondrial protein processing and protein-containing complex assembly. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (21452822..21469900)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (21794760..21811838)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial protein processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of m-AAA complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AFG3-like protein 2

Names: AFG3 ATPase family gene 3-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111197.1 → NP_001104667.1 AFG3-like protein 2

See identical proteins and their annotated locations for NP_001104667.1

Status: PROVISIONAL

Source sequence(s)

BC155655

UniProtKB/TrEMBL

A0A0R4IUQ8, A0A8M1NEZ0, A9JRG9

Related

ENSDARP00000138163.2, ENSDART00000169028.2

Conserved Domains (4) summary

TIGR01241
Location:248 → 741

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam00004
Location:340 → 471

AAA; ATPase family associated with various cellular activities (AAA)

pfam01434
Location:557 → 739

Peptidase_M41; Peptidase family M41

pfam06480
Location:141 → 237

FtsH_ext; FtsH Extracellular