fli1rs Fli-1 proto-oncogene, ETS transcription factor-related sequence [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fli1rsprovided by ZNC
Official Full Name: Fli-1 proto-oncogene, ETS transcription factor-related sequenceprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031114-3
See related: Ensembl:ENSDARG00000040080 AllianceGenome:ZFIN:ZDB-GENE-031114-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fli1b; zgc:5777174
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis; regulation of transcription, DNA-templated; and vasculogenesis. Predicted to be active in nucleus. Is expressed in endothelial cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (42017966..42046881)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (42067947..42096849)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate the requirement for Etv2 and Fli1b in tumor angiogenesis.
Title: ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis.
Etv2 alone is required for early vasculogenesis, whereas Etv2 and Fli1b function redundantly during late vasculogenesis and early embryonic angiogenesis.
Title: Etv2 and fli1b function together as key regulators of vasculogenesis and angiogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Fli-1 proto-oncogene, ETS transcription factor-related sequence; fli-1 proto-oncogene, ETS transcription factor b

Names: Fli-1 proto-oncogene, ETS transcription factor b; fli-1 homolog; friend leukemia integration 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008780.1 → NP_001008780.1 Fli-1 proto-oncogene, ETS transcription factor-related sequence

See identical proteins and their annotated locations for NP_001008780.1

Status: PROVISIONAL

Source sequence(s)

AY839950

UniProtKB/TrEMBL

Q5MBG6

Related

ENSDARP00000093564.2, ENSDART00000102789.4

Conserved Domains (2) summary

smart00413
Location:288 → 371

ETS; erythroblast transformation specific domain

cl15755
Location:117 → 206

SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

42017966..42046881

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158200.3 → XP_005158257.1 fli-1 proto-oncogene, ETS transcription factor b isoform X3

UniProtKB/TrEMBL

A0A8M2B528

Conserved Domains (2) summary

smart00413
Location:316 → 399

ETS; erythroblast transformation specific domain

cl15755
Location:117 → 206

SAM_superfamily; SAM (Sterile alpha motif )
XM_005158202.4 → XP_005158259.1 fli-1 proto-oncogene, ETS transcription factor b isoform X6

UniProtKB/TrEMBL

A0A8M2B4K4

Conserved Domains (2) summary

smart00413
Location:288 → 371

ETS; erythroblast transformation specific domain

cl15755
Location:89 → 178

SAM_superfamily; SAM (Sterile alpha motif )
XM_005158203.4 → XP_005158260.1 fli-1 proto-oncogene, ETS transcription factor b isoform X7

UniProtKB/TrEMBL

A0A8M2B4J8

Conserved Domains (2) summary

smart00413
Location:287 → 370

ETS; erythroblast transformation specific domain

cl15755
Location:89 → 178

SAM_superfamily; SAM (Sterile alpha motif )
XM_005158205.4 → XP_005158262.1 fli-1 proto-oncogene, ETS transcription factor b isoform X8

UniProtKB/TrEMBL

A0A8M2B4J0

Related

ENSDARP00000058612.5, ENSDART00000058613.6

Conserved Domains (2) summary

smart00413
Location:259 → 342

ETS; erythroblast transformation specific domain

cl15755
Location:89 → 178

SAM_superfamily; SAM (Sterile alpha motif )
XM_009292528.3 → XP_009290803.1 fli-1 proto-oncogene, ETS transcription factor b isoform X1

UniProtKB/TrEMBL

A0A8M3ATP1

Conserved Domains (2) summary

smart00413
Location:326 → 409

ETS; erythroblast transformation specific domain

cl15755
Location:127 → 216

SAM_superfamily; SAM (Sterile alpha motif )
XM_009292529.3 → XP_009290804.1 fli-1 proto-oncogene, ETS transcription factor b isoform X2

UniProtKB/TrEMBL

A0A8M3AQV9

Conserved Domains (2) summary

smart00413
Location:325 → 408

ETS; erythroblast transformation specific domain

cl15755
Location:127 → 216

SAM_superfamily; SAM (Sterile alpha motif )
XM_009292530.3 → XP_009290805.1 fli-1 proto-oncogene, ETS transcription factor b isoform X4

UniProtKB/TrEMBL

A0A8M3AID3

Conserved Domains (2) summary

smart00413
Location:298 → 381

ETS; erythroblast transformation specific domain

cl15755
Location:127 → 216

SAM_superfamily; SAM (Sterile alpha motif )
XM_009292531.3 → XP_009290806.1 fli-1 proto-oncogene, ETS transcription factor b isoform X5

UniProtKB/TrEMBL

A0A8M3B1W4

Conserved Domains (2) summary

smart00413
Location:297 → 380

ETS; erythroblast transformation specific domain

cl15755
Location:127 → 216

SAM_superfamily; SAM (Sterile alpha motif )