U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ctbp2a C-terminal binding protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 65230, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ctbp2aprovided by ZNC
    Official Full Name
    C-terminal binding protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010130-2
    See related
    Ensembl:ENSDARG00000044062 AllianceGenome:ZFIN:ZDB-GENE-010130-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctbp2; fe05b01; wu:fb96g03; wu:fe05b01; wu:fk19e02
    Summary
    Predicted to enable NAD binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and transcription corepressor activity. Acts upstream of or within camera-type eye development; nervous system development; and regulation of melanocyte differentiation. Predicted to be located in nucleus. Is expressed in nervous system; neural plate; otic vesicle; pectoral fin; and pharyngeal arch. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ctbp2a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (8596943..8692722, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (8439763..8535542, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 3b Neighboring gene keratinocyte associated protein 3 Neighboring gene testis expressed 36 Neighboring gene erythroid differentiation regulatory factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors. Zhang RW, et al. Nat Commun, 2016 Sep 2. PMID 27586999, Free PMC Article
    2. Rapid mapping of visual receptive fields by filtered back projection: application to multi-neuronal electrophysiology and imaging. Johnston J, et al. J Physiol, 2014 Nov 15. PMID 25172952, Free PMC Article
    3. Computational processing of optical measurements of neuronal and synaptic activity in networks. Dorostkar MM, et al. J Neurosci Methods, 2010 Apr 30. PMID 20152860, Free PMC Article
    4. Synaptic mitochondria regulate hair-cell synapse size and function. Wong HC, et al. Elife, 2019 Oct 14. PMID 31609202, Free PMC Article
    5. An amplitude code transmits information at a visual synapse. James B, et al. Nat Neurosci, 2019 Jul. PMID 31110322

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ribeye makes up most of the synaptic ribbon density in neuromast hair cells and is necessary for proper localization of calcium channels and synaptic ribbons.
      Title: Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.
    2. In photoreceptor cells, RIBEYE and RIM2 are expressed along the synaptic ribbon.
      Title: High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC191960

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within clustering of voltage-gated calcium channels IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gliogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of melanocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse assembly involved in innervation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    C-terminal-binding protein 2a
    Names
    C-terminal binding protein 2
    riba
    ribeye a

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195491.2 → NP_001182420.2  C-terminal-binding protein 2a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CU459182
      UniProtKB/TrEMBL
      Q5BU19
      Related
      ENSDARP00000124211.1, ENSDART00000148504.3

    2. NM_131715.2 → NP_571790.1  C-terminal-binding protein 2a isoform 2

      See identical proteins and their annotated locations for NP_571790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1, resulting in a protein that is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      CU459182
      UniProtKB/TrEMBL
      A0A8N1Z1U1, Q9DEG6
      Related
      ENSDARP00000123977.1, ENSDART00000148931.3
      Conserved Domains (2) summary
      COG0111
      Location:50 → 360
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:34 → 352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      8596943..8692722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools