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    sgo1 shugoshin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 791138, updated on 27-Mar-2024

    Summary

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    Official Symbol
    sgo1provided by ZNC
    Official Full Name
    shugoshin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-422
    See related
    Ensembl:ENSDARG00000103907 AllianceGenome:ZFIN:ZDB-GENE-070112-422
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sgol1; zgc:158297
    Summary
    Acts upstream of or within regulation of heart contraction. Predicted to be located in chromosome, centromeric region and nucleus. Predicted to be active in kinetochore. Is expressed in atrioventricular valve; heart; intestinal bulb; intestine; and sinus venosus. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sgo1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (48351550..48363436)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (48650536..48704044)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch73-359m17.6 Neighboring gene si:ch73-359m17.5 Neighboring gene ribosomal protein L14 Neighboring gene transfer RNA proline (anticodon AGG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish cohesin protein Sgo1 is required for cardiac function and eye development. Kamel SM, et al. Dev Dyn, 2022 Aug. PMID 35275424, Free PMC Article
    2. Reduced sister chromatid cohesion acts as a tumor penetrance modifier. Wang J, et al. PLoS Genet, 2022 Aug. PMID 35994499, Free PMC Article
    3. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Chetaille P, et al. Nat Genet, 2014 Nov. PMID 25282101
    4. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of retina cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal pigment epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    shugoshin 1; shugoshin-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080620.1 → NP_001074089.1  shugoshin 1

      See identical proteins and their annotated locations for NP_001074089.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129193
      UniProtKB/TrEMBL
      A1L1S4
      Related
      ENSDARP00000136487.1, ENSDART00000169729.2
      Conserved Domains (1) summary
      pfam07557
      Location:555 → 579
      Shugoshin_C; Shugoshin C terminus

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      48351550..48363436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468141.1 → XP_021323816.1  shugoshin-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PNJ5
      Conserved Domains (1) summary
      pfam07557
      Location:498 → 521
      Shugoshin_C; Shugoshin C terminus
    Nucleotide Protein
    Heading Accession and Version

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