vbp1 von Hippel-Lindau binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vbp1provided by ZNC
Official Full Name: von Hippel-Lindau binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-494
See related: Ensembl:ENSDARG00000030241 AllianceGenome:ZFIN:ZDB-GENE-050522-494
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7140038; zgc:110686
Summary: Predicted to enable tubulin binding activity. Predicted to be involved in microtubule-based process and tubulin complex assembly. Predicted to be part of polysome and prefoldin complex. Predicted to be active in cytoplasm. Is expressed in alar plate midbrain region; immature eye; myotome; neural plate; and optic tectum. Orthologous to human VBP1 (VHL binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (23887728..23894685, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (23616571..23623528, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1alpha but not HIF-2alpha.
Title: VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule-based process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prefoldin subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.