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    ssh2a slingshot protein phosphatase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 325085, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ssh2aprovided by ZNC
    Official Full Name
    slingshot protein phosphatase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3810
    See related
    Ensembl:ENSDARG00000088440 AllianceGenome:ZFIN:ZDB-GENE-030131-3810
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ssh2; wu:fc54g05
    Summary
    Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ssh2a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (28548625..28587088, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (28615752..28654281, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase interacting ArfGAP 1 Neighboring gene ankyrin repeat domain 13B Neighboring gene si:ch211-225b7.5 Neighboring gene solute carrier family 6 member 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of the tbx6/16 subfamily genes in vertebrates: insights from zebrafish. Ahn D, et al. Mol Biol Evol, 2012 Dec. PMID 22915831
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase Slingshot homolog 2
    Names
    slingshot homolog 2
    slingshot homolog 2a
    XP_001921323.1
    XP_005157728.1
    XP_021322116.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      28548625..28587088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001921288.7 → XP_001921323.1  protein phosphatase Slingshot homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M1QV03, X1WFY2
      Related
      ENSDARP00000129137.1, ENSDART00000156049.2
      Conserved Domains (3) summary
      cd11652
      Location:3 → 238
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:310 → 445
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:253 → 304
      DEK_C; DEK C terminal domain

    2. XM_005157671.4 → XP_005157728.1  protein phosphatase Slingshot homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B4L4, E7FH10
      Related
      ENSDARP00000112052.1, ENSDART00000127845.3
      Conserved Domains (3) summary
      cd11652
      Location:12 → 245
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:317 → 452
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:260 → 311
      DEK_C; DEK C terminal domain

    3. XM_021466441.1 → XP_021322116.1  protein phosphatase Slingshot homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PIQ4
      Conserved Domains (3) summary
      cd11652
      Location:12 → 245
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:317 → 452
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:259 → 311
      DEK_C; DEK C terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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